An ECM-derived peptide
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Product Categories

Product Type

Biochemicals
Peptides

Research Area

Immunology & Inflammation
Pulmonary Diseases

GHK

Item No. 27168

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-histidyl-L-lysine
CAS Number
49557-75-7
Synonyms
  • Gly-His-Lys
  • NSC 379527
Molecular Formula
C14H24N6O4
Formula Weight
340.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 2.5mg/mLPBS (pH 7.2): 10mg/mL
SMILES
O=C(N[C@H](C(O)=O)CCCCN)[C@@H](NC(CN)=O)CC1=CN=CN1
InChi Code
InChI=1S/C14H24N6O4/c15-4-2-1-3-10(14(23)24)20-13(22)11(19-12(21)6-16)5-9-7-17-8-18-9/h7-8,10-11H,1-6,15-16H2,(H,17,18)(H,19,21)(H,20,22)(H,23,24)/t10-,11-/m0/s1
InChi Key
MVORZMQFXBLMHM-QWRGUYRKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $120

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    10 mg

    $169

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    Product Description

    GHK is a peptide released during extracellular matrix (ECM) protein degradation following tissue injury.1 It binds to copper to form GHK-Cu, a complex with diverse biological activities, including roles in tissue remodeling and wound healing, hair growth, and suppression of inflammation. GHK (1 µM) increases keratinocyte proliferation in vitro, as well as the number of cells positive for the keratinocyte stem cell marker p63 and the protein levels of integrin α6 and β1 in a skin equivalent model.2 It also reduces infiltration of inflammatory cells and decreases TNF-α and IL-6 protein levels in bronchoalveolar lavage fluid (BALF) in a mouse model of pulmonary fibrosis induced by bleomycin (Item No. 13877).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pickart, L. The human tri-peptide GHK and tissue remodeling. J. Biomater. Sci. Polym. Ed. 19(8), 969-988 (2008).

    2. Choi, H.-R., Kang, Y.-A., Ryoo, S.-J., et al. Stem cell recovering effect of copper-free GHK in skin. J. Pept. Sci. 18(11), 685-690 (2012).

    3. Zhou, X.-M., Wang, G.-L., Wang, X.-B., et al. GHK peptide inhibits bleomycin-induced pulmonary fibrosis in mice by suppressing TGFβ1/Smad-mediated epithelial-to-mesenchymal transition. Front. Pharmacol. 8, 904 (2017).