A nonpeptide substrate of proteases and deiminases
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N-α-Benzoyl-L-Arginine ethyl ester (hydrochloride)

Item No. 27183

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2-benzoyl-L-arginine, ethyl ester, monohydrochloride
CAS Number
2645-08-1
Synonyms
  • BAEE
  • Bz-Arg-OEt
  • NSC 86159
Molecular Formula
C15H22N4O3 • HCl
Formula Weight
342.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
227 nm
SMILES
O=C(N[C@H](C(OCC)=O)CCCNC(N)=N)C1=CC=CC=C1.Cl
InChi Code
InChI=1S/C15H22N4O3.ClH/c1-2-22-14(21)12(9-6-10-18-15(16)17)19-13(20)11-7-4-3-5-8-11;/h3-5,7-8,12H,2,6,9-10H2,1H3,(H,19,20)(H4,16,17,18);1H/t12-;/m0./s1
InChi Key
HIXDELXKSSLIKB-YDALLXLXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $54

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    10 g

    $102

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    50 g

    $238

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    Product Description

    N-α-Benzoyl-L-arginine ethyl ester (BAEE) is a nonpeptide substrate of proteases and deiminases.1,2,3,4,5 It has been used as a substrate for the relative quantification of trypsin activity.1,2 BAEE has also been used as a substrate for the activity of subtilisins, kallikreins, and protein arginine deiminase 4 (PAD4).3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Crowell, A.M.J., Stewart, E.J., Take, Z.S., et al. Critical assessment of the spectroscopic activity assay for monitoring trypsin activity in organic-aqueous solvent. Anal. Biochem. 435(2), 131-136 (2013).

    2. Rajabi, M., Shareghi, B., Farhadian, S., et al. Evaluation of maltose on conformation and activity parameters of trypsin. J. Biomol. Struct. Dyn. 37(17), 4557-4562 (2019).

    3. Glazer, A.N. Esteratic reactions catalyzed by subtilisins. The Journal of Biological Chemisty 242(3), 433-436 (1967).

    4. Ran, X., Zhang, Q., and Wang, D.W. Tissue kallikrein activity, detected by a novel method, may be a predictor of recurrent stroke: A case-control study. Dis. Markers 159750 (2015).

    5. Kearney, P.L., Bhatia, M., Jones, N.G., et al. Kinetic characterization of protein arginine deiminase 4: A transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis. Biochemistry 44(31), 10570-10582 (2005).