A 5-HT1A receptor agonist
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Oleanolic Acid Acrylate

Item No. 27206

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3β-[(1-oxo-2-propen-1-yl)oxy]-olean-12-en-28-oic acid
CAS Number
1975976-24-9
Synonyms
  • OAA
Molecular Formula
C33H50O4
Formula Weight
510.7
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30mg/mLDMSO: 20mg/mLEthanol: 30mg/mLEthanol:PBS (pH 7.2) (1:40): 0.02mg/mL
SMILES
CC1(C)CC[C@]2(C(O)=O)CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](OC(C=C)=O)CC[C@]5(C)[C@@]4([H])CC=C3[C@]2([H])C1
InChi Code
InChI=1S/C33H50O4/c1-9-26(34)37-25-13-14-30(6)23(29(25,4)5)12-15-32(8)24(30)11-10-21-22-20-28(2,3)16-18-33(22,27(35)36)19-17-31(21,32)7/h9-10,22-25H,1,11-20H2,2-8H3,(H,35,36)/t22-,23-,24+,25-,30-,31+,32+,33-/m0/s1
InChi Key
SEOUKQFSVNKQNN-FBXMHRQLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $213

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    10 mg

    $376

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    Product Description

    Oleanolic acid acrylate (OAA) is an agonist of the serotonin (5-HT) receptor subtype 5-HT1A and a derivative of oleanolic acid (Item No. 11726).1 It acts as an agonist at the 5-HT1A receptor in mouse hippocampal homogenates in a [35S]GTPγS binding assay (EC50 = 0.79 µM). It is also a selective inhibitor of MAO-A over MAO-B (IC50s = 48.8 µM and >100 µM, respectively). In mice, OAA (10 mg/kg) reduces immobility in the forced swim test and increases the number of crossings and time spent at the center in the open field test, indicating anti-depressant-like and anxiolytic activities.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fajemiroye, J.O., Polepally, P.R., Chaurasiya, N.D., et al. Oleanolic acid acrylate elicits antidepressant-like effect mediated by 5-HT1A receptor. Sci. Rep. 5, 11582 (2015).