A lignan with diverse biological activities
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Schizandrin

Item No. 27211

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6S,7S,12aR)-5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-dibenzo[a,c]cycloocten-6-ol
CAS Number
7432-28-2
Synonyms
  • (+)-Schizandrin
  • Schizandrol A
Molecular Formula
C24H32O7
Formula Weight
432.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH7.2) (1:2): 0.3 mg/mlDMSO: 5 mg/mlEthanol: 2 mg/ml
λmax
218, 252 nm
SMILES
COC1=C(OC)C(OC)=CC2=C1C3=C(C=C(OC)C(OC)=C3OC)C[C@@](O)(C)[C@@H](C)C2
InChi Code
InChI=1S/C24H32O7/c1-13-9-14-10-16(26-3)20(28-5)22(30-7)18(14)19-15(12-24(13,2)25)11-17(27-4)21(29-6)23(19)31-8/h10-11,13,25H,9,12H2,1-8H3/t13-,24-/m0/s1
InChi Key
YEFOAORQXAOVJQ-RZFZLAGVSA-N
Origin
Plant/Schisandra chinensis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $63

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    50 mg

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    100 mg

    $481

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    250 mg

    $976

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    Product Description

    Schizandrin is a dibenzocyclooctadiene lignan and a major component of S. chinensis and has diverse biological activities.1,2,3,4,5 It induces cell cycle arrest at the G0/G1 phase and inhibits growth of T47D and MDA-MB-231 breast cancer cells when used at a concentration of 100 μM.1 Schizandrin (10 and 100 μM) prevents glutamate-induced cytotoxicity, inhibits production of nitric oxide (NO) and reactive oxygen species (ROS), and preserves the mitochondrial membrane potential in isolated rat cortical cells.2 It reduces apoptosis induced by cisplatin (Item No. 13119) in HK-2 human kidney cells.3 In vivo, schizandrin (1 and 10 mg/kg, p.o.) reverses scopolamine-induced impairment of spatial memory and the passive avoidance response in rats.4 It enhances oxotremorine-induced tremors in mice. Schizandrin (10 mg/kg) reduces serum levels of IgE, IgG1, IL-4, and IFN-γ in an ovalbumin-sensitized mouse model of allergy.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, S.-J., Min, H.-Y., Lee, E.J., et al. Growth inhibition and cell cycle arrest in the G0/G1 by schizandrin, a dibenzocyclooctadiene lignan isolated from Schisandra chinensis, on T47D human breast cancer cells. Phytother. Res. 24(2), 193-197 (2010).

    2. Cheng, H.-Y., Hsieh, M.-T., Wu, C.-R., et al. Schizandrin protects primary cultures of rat cortical cells from glutamate-induced excitotoxicity. J. Pharmacol. Sci. 107(1), 21-31 (2008).

    3. Bunel, V., Antoine, M.-H., Nortier, J., et al. Protective effects of schizandrin and schizandrin B towards cisplatin nephrotoxicity in vitro. J. Appl. Toxicol. 34(12), 1311-1319 (2013).

    4. Egashira, N., Kurauchi, K., Iwasaki, K., et al. Schizandrin reverses memory impairment in rats. Phytother. Res. 22(1), 49-52 (2008).

    5. Han, N.-R., Moon, P.-D., Kim, N.-R., et al. Schisandra chinensis and its main constituent schizandrin attenuate allergic reactions by down-regulating caspase-1 in ovalbumin-sensitized mice. Am. J. Chin. Med. 45(1), 159-172 (2017).