A synthetic progestin
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Isomer(s)
18217Gestodene
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Altrenogest

Item No. 27218

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(17β)-17-hydroxy-17-(2-propen-1-yl)-estra-4,9,11-trien-3-one
CAS Number
850-52-2
Synonyms
  • Allyltrenbolone
  • DRC 6246
  • RU 2267
Molecular Formula
C21H26O2
Formula Weight
310.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 0.1 mg/mlEthanol: 20 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
λmax
242, 342 nm
SMILES
O=C1CCC2=C3[C@@]([C@@](CC[C@@]4(O)CC=C)([H])[C@]4(C)C=C3)([H])CCC2=C1
InChi Code
InChI=1S/C21H26O2/c1-3-10-21(23)12-9-19-18-6-4-14-13-15(22)5-7-16(14)17(18)8-11-20(19,21)2/h3,8,11,13,18-19,23H,1,4-7,9-10,12H2,2H3/t18-,19+,20+,21+/m1/s1
InChi Key
VWAUPFMBXBWEQY-ANULTFPQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Altrenogest is a synthetic progestin and an agonist of progesterone and androgen receptors (EC50s = 0.64 and 0.63 nM, respectively, in S. cerevisiae cells expressing human receptors).1 In vivo, altrenogest (20 mg/animal per day) reduces testicular weight, sperm content, and serum levels of luteinizing hormone and testosterone in boars.2 Altrenogest (0.044 mg/kg) increases serum concentrations of equine chorionic gonadotropin and embryonic size in pregnant mares.3 It also decreases genital perfusion and increases estrus cycle length in mares.4 Formulations containing altrenogest have been used to synchronize estrus in horses and pigs.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McRobb, L., Handelsman, D.J., Kazlauskas, R., et al. Structure-activity relationships of synthetic progestins in a yeast-based in vitro androgen bioassay. J. Steroid Biochem. Mol. Biol. 110(1-2), 39-47 (2008).

    2. Kluber, E.F., III, Minton, J.E., Stevenson, J.S., et al. Growth, carcass traits, boar odor and testicular and endocrine functions of male pigs fed a progestogen, altrenogest. J. Anim. Sci. 66(2), 470-478 (1988).

    3. Willmann, C., Schuler, G., Hoffmann, B., et al. Effects of age and altrenogest treatment on conceptus development and secretion of LH, progesterone and eCG in early-pregnant mares. Theriogenology 75(3), 421-428 (2011).

    4. Bollwein, H., Kolberg, B., and Stolla, R. The effect of exogenous estradiol benzoate and altrenogest on uterine and ovarian blood flow during the estrous cycle in mares. Theriogenology 61(6), 1137-1146 (2004).