A reversible Kif18A inhibitor
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BTB-1

Item No. 27219

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-chloro-2-nitro-1-(phenylsulfonyl)-benzene
CAS Number
86030-08-2
Synonyms
  • NSC 156750
  • NSC 658180
Molecular Formula
C12H8ClNO4S
Formula Weight
297.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10mg/mLDMSO: 10mg/mLDMSO:PBS (pH 7.2) (1:3): .25mg/mLEthanol: 3mg/mL
λmax
231 nm
SMILES
O=S(C1=CC=CC=C1)(C2=CC=C(Cl)C=C2[N+]([O-])=O)=O
InChi Code
InChI=1S/C12H8ClNO4S/c13-9-6-7-12(11(8-9)14(15)16)19(17,18)10-4-2-1-3-5-10/h1-8H
InChi Key
VZDUQPHKUBZMLW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $44

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    500 mg

    $110

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    1 g

    $156

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    Product Description

    BTB-1 is a reversible inhibitor of the kinesin-8 family motor protein Kif18A (IC50 = 1.69 μM).1 It is selective for Kif18A over a panel of seven kinesins at 100 μM. BTB-1 (100 μM) inhibits Kif18A-dependent microtubule motility in a microtubule gliding assay. It induces mitotic accumulation of HeLa cells in a dose-dependent manner.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Catarinella, M., Grüner, T., Strittmatter, T., et al. BTB-1: A small molecule inhibitor of the mitotic motor protein Kif18A. Angew. Chem. Int. Ed. Engl. 48(48), 9072-9076 (2009).