A salvianolic acid with diverse biological activities
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Danshensu (sodium salt)

Item No. 27222

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α,3,4-trihydroxy-benzenepropanoic acid, monosodium salt
CAS Number
67920-52-9
Molecular Formula
C9H9O5 • Na
Formula Weight
220.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: Partially solubleDMSO: 1 mg/mlEthanol: Partially solublePBS (pH 7.2): 10 mg/ml
λmax
217, 257, 283, 330 nm
SMILES
OC1=C(O)C=CC(CC(O)C([O-])=O)=C1.[Na+]
InChi Code
InChI=1S/C9H10O5.Na/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14;/h1-3,8,10-12H,4H2,(H,13,14);/q;+1/p-1
InChi Key
ZMMKVDBZTXUHFO-UHFFFAOYSA-M
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $38

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    25 mg

    $87

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    50 mg

    $156

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    100 mg

    $291

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    Cayman Chemical
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    Product Description

    Danshensu is a salvianolic acid and the major component of S. miltiorrhiza (Danshen) and has diverse biological activities.1,2,3,4 It reduces expression of the autophagy-associated proteins p62, LC3-II, and Beclin-1 and the apoptosis-related proteins Bax and caspase-3, prevents cardiomyocyte damage, and increases heart rate, coronary flow (CF), and left ventricular developed pressure (LVDP) in an isolated rat heart model of ischemia and reperfusion injury.1 Danshensu (60 mg/kg per day) reduces infarct size and improves left ventricular function in a rat model of myocardial infarction.2 It enhances radiation-induced tumor cell death in a Lewis lung carcinoma mouse xenograft model.3 Danshensu also decreases infarct volume, neuronal apoptosis, production of TNF-α, IL-1β, and IL-6, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity in a rat model of cerebral ischemia and reperfusion injury.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fan, G., Yu, J., Asare, P.F., et al. Danshensu alleviates cardiac ischaemia/reperfusion injury by inhibiting autophagy and apoptosis via activation of mTOR signalling. J. Cell Mol. Med. 20(10), 1908-1919 (2016).

    2. Yin, Y., Duan, J., Guo, C., et al. Danshensu accelerates angiogenesis after myocardial infarction in rats and promotes the functions of endothelial progenitor cells through SDF-1α/CXCR4 axis. Eur. J. Pharmacol. 814, 274-282 (2017).

    3. Cao, H.Y., Ding, R.L., Li, M., et al. Danshensu, a major water-soluble component of Salvia miltiorrhiza, enhances the radioresponse for Lewis Lung Carcinoma xenografts in mice. Oncol. Lett. 13(2), 605-612 (2017).

    4. Xu, H., Liu, W., Liu, T., et al. Synergistic neuroprotective effects of Danshensu and hydroxysafflor yellow A on cerebral ischemia-reperfusion injury in rats. Oncotarget 8(70), 115434-115443 (2017).