An antispasmodic agent
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Biochemicals

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Neuroscience
Pain Research

Scopolamine N-butyl (bromide)

Item No. 27223

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1α,2β,4β,5α,7β)-9-butyl-7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane, monobromide
CAS Number
149-64-4
Synonyms
  • Hyoscine butobromide
  • N-butyl Hyoscine
Molecular Formula
C21H30NO4 • Br
Formula Weight
440.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 5 mg/mlEthanol: 2.5 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
273 nm
SMILES
O=C(O[C@@H]1C[C@@H]([N@+]2(CCCC)C)[C@H]3O[C@H]3[C@@H]2C1)[C@H](CO)C4=CC=CC=C4.[Br-]
InChi Code
InChI=1S/C21H30NO4.BrH/c1-3-4-10-22(2)17-11-15(12-18(22)20-19(17)26-20)25-21(24)16(13-23)14-8-6-5-7-9-14;/h5-9,15-20,23H,3-4,10-13H2,1-2H3;1H/q+1;/p-1/t15-,16-,17-,18+,19-,20+,22-;/m1./s1
InChi Key
HOZOZZFCZRXYEK-UBNOCOESSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $49

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    5 g

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    10 g

    $329

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    Product Description

    Scopolamine N-butyl is an antispasmodic agent.1,2 In vivo, scopolamine N-butyl inhibits electrically induced urinary bladder contractions in dogs (ED50s = 0.07-4.7 mg/kg).1 It also decreases the ileal phasic motility index (PMI) as well as colonic motility in canine models of ileal and colonic fistulas, respectively.2 Formulations containing scopolamine N-butyl have been used in the treatment of pain induced by abdominal cramps and bladder spasms.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bauer, R., and Wick, H. Comparative spasmolytic potencies of atropine sulphate and N-butyl hyoscine bromide following intravenous injection, injection into a mesenteric vein, and intraduodenal instillation. J. Pharm. Pharmacol. 21(10), 706-708 (1969).

    2. Sagrada, A., Schiavone, A., Cefalá, A., et al. N-butyl hyoscine exerts local spasmolytic effect in the small and large bowel of the conscious dog. Arch. Int. Pharmacodyn. Ther. 287(2), 237-247 (1987).