A uPA inhibitor
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UK 371804

Item No. 27225

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[1-[(aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methyl-alanine
CAS Number
256477-09-5
Molecular Formula
C14H16ClN5O4S
Formula Weight
385.8
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/ml
SMILES
ClC1=CN=C(NC(N)=N)C2=C1C=CC(S(NC(C)(C)C(O)=O)(=O)=O)=C2
InChi Code
InChI=1S/C14H16ClN5O4S/c1-14(2,12(21)22)20-25(23,24)7-3-4-8-9(5-7)11(19-13(16)17)18-6-10(8)15/h3-6,20H,1-2H3,(H,21,22)(H4,16,17,18,19)
InChi Key
XSDAXWRCPTYNOD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $107

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    10 mg

    $203

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    25 mg

    $451

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    Product Description

    UK 371804 is an inhibitor of urokinase-type plasminogen activator (uPA; Ki = 10 nM).1 It is 4,000- and 2,700-fold selective for uPA over tissue plasminogen activator (tPA) and plasmin, respectively. UK 371804 inhibits exogenous uPA in human chronic wound fluid (IC50 = 0.89 μM). Topical administration of UK 371804 inhibits exogenous uPA activity in a porcine excisional wound model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fish, P.V., Barber, C.G., Brown, D.G., et al. Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-Sulfonamidoisoquinolinyl)guanidines. J. Med. Chem. 50(10), 2341-2351 (2007).