An agonist of muscarinic acetylcholine receptors
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Iperoxo (iodide)

Item No. 27235

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(4,5-dihydro-3-isoxazolyl)oxy]-N,N,N-trimethyl-2-butyn-1-aminium, monoiodide
CAS Number
247079-84-1
Molecular Formula
C10H17N2O2 • I
Formula Weight
324.2
Purity
≥98%
Formulation (Request formulation change)
A solid
λmax
225 nm
SMILES
C[N+](C)(C)CC#CCOC1=NOCC1.[I-]
InChi Code
InChI=1S/C10H17N2O2.HI/c1-12(2,3)7-4-5-8-13-10-6-9-14-11-10;/h6-9H2,1-3H3;1H/q+1;/p-1
InChi Key
XWEOIAMCTHLJJB-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $44

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    5 mg

    $195

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    10 mg

    $344

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    Product Description

    Iperoxo is an agonist of muscarinic acetylcholine receptors.1,2 It stimulates [35S]GTPγS binding to CHO cell membranes expressing human M2 muscarinic receptors and cell membranes expressing M4 muscarinic receptors (EC50s = 2.12 and 8.47 nM, respectively).1 Iperoxo induces M1-dependent inhibition of the twitch response in electrically-stimulated isolated rabbit vas deferens (pD2 = 9.87) and M3-mediated contraction of isolated guinea pig ileum (pD2 = 9.78).2 In vivo, iperoxo reduces formalin-induced paw licking and acetic acid-induced writhing in mice (ED50s = 0.004 and 0.001 mg/kg, respectively).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Croy, C.H., Schober, D.A., Xiao, H., et al. Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M2 and M4 receptors. Mol. Pharmacol. 86(1), 106-115 (2014).

    2. Dallanoce, C., Conti, P., De Amici, M., et al. Synthesis and functional characterization of novel derivatives related to oxotremorine and oxotremorine-M. Bioorg. Med. Chem. 7(8), 1539-1547 (1999).

    3. Barocelli, E., Ballabeni, V., Bertoni, S., et al. Evidence for specific analgesic activity of a muscarinic agonist selected among a new series of acetylenic derivatives. Life Sci. 68(15), 1775-1785 (2001).