An inhibitor of autotaxin
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BMP-22

Item No. 27264

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
p-[(4-pentadecylphenyl)methyl]-phosphonic acid
CAS Number
1306684-90-1
Molecular Formula
C22H39O3P
Formula Weight
382.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlEthanol: 10 mg/ml
λmax
220, 265 nm
SMILES
OP(CC1=CC=C(CCCCCCCCCCCCCCC)C=C1)(O)=O
InChi Code
InChI=1S/C22H39O3P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-21-16-18-22(19-17-21)20-26(23,24)25/h16-19H,2-15,20H2,1H3,(H2,23,24,25)
InChi Key
XWVBRTAQHMKHCE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $219

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    5 mg

    $657

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    10 mg

    $1,095

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    25 mg

    $2,189

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    Cayman Chemical
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    Product Description

    BMP-22 is an inhibitor of autotaxin (IC50 = 170 nM).1 It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7 at 10 μM. BMP-22 (0.1-1,000 nM) inhibits autotaxin-mediated production of lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC; Item No. 24331) in vitro in a concentration-dependent manner. It inhibits LPC-dependent MM1 cell invasion of a human umbilical vein endothelial cell (HUVEC) monolayer. BMP-22 (0.5 mg/kg per day) decreases the number of lung metastatic foci in a B16/F10 syngeneic mouse melanoma model of lung metastasis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gupte, R., Patil, R., Liu, J., et al. Benzyl and naphthalene-methyl phosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic actions. ChemMedChem 6(5), 922-935 (2011).