A fungal metabolite
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Pachybasin

Item No. 27268

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-hydroxy-3-methyl-9,10-anthracenedione
CAS Number
2549-78-2
Synonyms
  • 1-Hydroxy-3-methylanthraquinone
Molecular Formula
C15H10O3
Formula Weight
238.2
Purity
≥70%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Dichloromethane: solubleDMSO: solubleEthanol: solubleMethanol: soluble
SMILES
O=C1C2=C(C(O)=CC(C)=C2)C(C3=CC=CC=C31)=O
InChi Code
InChI=1S/C15H10O3/c1-8-6-11-13(12(16)7-8)15(18)10-5-3-2-4-9(10)14(11)17/h2-7,16H,1H3
InChi Key
AFHWNNJNTNLCQF-UHFFFAOYSA-N
Origin
Fungus/Unidentified sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $75

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    Product Description

    Pachybasin is an anthraquinone fungal metabolite.1,2,3 It inhibits the growth of E. coli, S. aureus, B. subtilis, and M. luteus bacteria (MICs = 64, 32, 64, and 64 μg/ml, respectively) and C. albicans, S. cerevisiae, A. niger, A. flavus, and F. oxysporum fungi (MICs = 64, 64, 64, 64, and 16 μg/ml, respectively).1 It also induces germ tube malformation in B. graminis fungi.2 Pachybasin induces developmental retardation and notochord distortions and increases mortality in zebrafish embryos when used at concentrations ranging from 1 to 100 μM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wulansari, D., Jamal, Y., Tiwi, P., et al. Pachybasin, a major metabolite from culture broth of endophytic coelomyceteous AFKR-18 fungus isolated from a yellow moonsheed plant, Arcangelisia flava (L.) Merr. HAYATI J. Biosci. 21(2), 95-100 (2014).

    2. Hildebrandt, U., Marsell, A., and Riederer, M. Direct effects of physcion, chrysophanol, emodin, and pachybasin on germination and appressorium formation of the barley (Hordeum vulgare L.) powdery mildew fungus Blumeria graminis f. sp. hordei (DC.) Speer. J. Agric. Food Chem. 66(13), 3393-3401 (2018).

    3. Lin, Y.-R., Peng, K.-C., Chan, M.-H., et al. Effect of pachybasin on general toxicity and developmental toxicity in vivo. J. Agric. Food Chem. 65(48), 10489-10494 (2017).