For immunochemical detection of GA-pyridine
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AGE (GA-Pyridine Specific) Monoclonal Antibody (Clone 3G2)

Item No. 27272

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Advanced Glycation End Products (Glycolaldehyde-pyridine)
Immunogen
GA-pyridine-BSA
Clone Designation
3G2
Formulation (Request formulation change)
100 µg of protein G-purified monoclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Host
Mouse
Isotype
IgG2b
Applications
ELISA, WB
Cross Reactivity
(-) (Carboxyethyl)-lysine (CEL)(-) Glyoxal (GO)(-) Methyl-glyoxal (MG)
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µg

    $395

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    Product Description

    Glycolaldehyde-pyridine (GA-pyridine) is an advanced glycation end product (AGE).1,2 It is formed via the reaction of GA, a product of myeloperoxidase activity, with lysine and can therefore serve as an antigenic marker of protein modification resulting from myeloperoxidase activity.1 GA-pyridine has been detected in the tubular epithelial cells, renal vasculature, and glomerular epithelium of both healthy and diseased human kidneys, and accumulates in the glomerular mesangium of patients with renal diseases, including diabetic nephropathy, Wegener's granulomatosis, mesangial proliferative glomerulonephritis, and focal glomerular sclerosis.2 GA-pyridine also accumulates in the cytoplasm of foam cells and extracellularly in the atheromatous core of human atherosclerotic lesions.1 Cayman's AGE (GA-Pyridine Specific) Monoclonal Antibody (Clone 3G2) can be used for Western blot and ELISA applications. This antibody recognizes GA AGE-modified proteins.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nagai, R., Hayashi, C.M., Xia, L., et al. Identification in human atherosclerotic lesions of GA-pyridine, a novel structure derived from glycolaldehyde-modified proteins. The Journal of Biological Chemisty 277(50), 48905-48912 (2002).

    2. Greven, W.L., Waanders, F., Nagai, R., et al. Mesangial accumulation of GA-pyridine, a novel glycolaldehyde-derived AGE, in human renal disease. Kidney Int. 68(2), 595-602 (2005).