A peptide fragment of ACTH
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ACTH (1-16) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

Item No. 27273

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α1-16-corticotropin, trifluoroacetate salt
Synonyms
  • Adrenocorticotropic Hormone (1-16)
  • SYSMEHFRWGKPVGKK-OH
Molecular Formula
C89H133N25O22S • XCF3COOH
Formula Weight
1937.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@@H](CO)C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(N[C@@H](CCCCN)C(N1CCC[C@H]1C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)CC2=CNC3=C2C=CC=C3)=O)=O)CC4=CC=CC=C4)=O)CC5=CN=CN5)=O)=O)CCSC)=O)=O)CC6=CC=C(O)C=C6)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C89H133N25O22S.C2HF3O2/c1-50(2)74(86(133)100-46-71(118)102-59(21-9-12-33-90)77(124)107-64(88(135)136)23-11-14-35-92)113-85(132)70-25-16-37-114(70)87(134)63(22-10-13-34-91)103-72(119)45-99-76(123)67(41-53-43-98-58-20-8-7-19-56(53)58)110-78(125)60(24-15-36-97-89(94)95)104-81(128)66(39-51-17-5-4-6-18-51)109-83(130)68(42-54-44-96-49-101-54)111-79(126)61(30-31-73(120)121)105-80(127)62(32-38-137-3)106-84(131)69(48-116)112-82(129)65(108-75(122)57(93)47-115)40-52-26-28-55(117)29-27-52;3-2(4,5)1(6)7/h4-8,17-20,26-29,43-44,49-50,57,59-70,74,98,115-117H,9-16,21-25,30-42,45-48,90-93H2,1-3H3,(H,96,101)(H,99,123)(H,100,133)(H,102,118)(H,103,119)(H,104,128)(H,105,127)(H,106,131)(H,107,124)(H,108,122)(H,109,130)(H,110,125)(H,111,126)(H,112,129)(H,113,132)(H,120,121)(H,135,136)(H4,94,95,97);(H,6,7)/t57-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,74-;/m0./s1
InChi Key
VLUHHQASIZOHOW-VYYWJQDKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    ACTH (1-16) is a peptide fragment of adrenocorticotropic hormone (ACTH; Item No. 24257), a peptide hormone found in the brain that is involved in the biological stress response.1 It binds to melanocortin receptors (MCRs; Kis = 0.267, 19, 698, and 2,600 nM for MC1R, MC3R, MC4R, and MC5R, respectively).2 ACTH (1-16) (160 µg/kg, i.v.) increases mean arterial blood pressure (MAP) following bleeding-induced hypotension in a rat model of hemorrhagic shock 15-30 minutes after administration.3 It increases grooming behavior and the incidence of stretching and yawning syndrome (SYS) in rats when administered intraventricularly at 0.05 or 2 μg.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Strand, F.L., Lee, S.J., Zuccarelli, L.A., et al. Non-corticotropic ACTH peptides modulate nerve development and regeneration. Rev. Neurosci. 4(4), 321-363 (1993).

    2. Schiöth, H.B., Muceniece, R., Larsson, M., et al. The melanocortin 1, 3, 4 or 5 receptors do not have a binding epitope for ACTH beyond the sequence of α-MSH. J. Endocrinol. 155(1), 73-78 (1997).

    3. Bertolini, A., Guarini, S., Rompianesi, E., et al. α-MSH and other ACTH fragments improve cardiovascular function and survival in experimental hemorrhagic shock. Eur. J. Pharmacol. 130(1-2), 19-26 (1986).

    4. Gispen, W.H., Wiegant, V.M., Greven, H.M., et al. The induction of excessive grooming in the rat by intraventricular application of peptides derived from ACTH: Structure-activity studies. Life Sci. 17(4), 645-652 (1975).