A peptide fragment of ACTH
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ACTH (18-39) (human)

Item No. 27274

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
53917-42-3
Synonyms
  • Adrenocorticotropic Hormone (18-39)
  • Corticotropin-like Intermediate Lobe Peptide
  • RPVKVYPNGAEDESAEAFPLEF
Molecular Formula
C112H165N27O36
Formula Weight
2465.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 2.5 mg/mlDMSO: 5 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
[H]N[C@@H](CCCNC(N)=N)C(N1CCC[C@H]1C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@H](C(N2CCC[C@H]2C(N[C@@H](CC(N)=O)C(NCC(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@H](C(N3CCC[C@H]3C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)CC5=CC=CC=C5)=O)C)=O)=O)C)=O)=O)=O)CC(O)=O)=O)=O)C)=O)=O)=O)=O)CC6=CC=C(O)C=C6)=O)=O)=O)=O)=O
InChi Code
InChI=1S/C112H165N27O36/c1-56(2)48-72(100(163)125-70(37-41-86(148)149)97(160)133-77(111(174)175)51-63-24-14-11-15-25-63)129-103(166)79-28-20-46-138(79)109(172)75(49-62-22-12-10-13-23-62)131-93(156)61(9)121-95(158)68(35-39-84(144)145)123-92(155)60(8)122-102(165)78(55-140)134-98(161)71(38-42-87(150)151)126-101(164)74(53-88(152)153)128-96(159)69(36-40-85(146)147)124-91(154)59(7)120-83(143)54-119-94(157)73(52-82(115)142)130-104(167)80-29-21-47-139(80)110(173)76(50-64-31-33-65(141)34-32-64)132-107(170)89(57(3)4)135-99(162)67(27-16-17-43-113)127-106(169)90(58(5)6)136-105(168)81-30-19-45-137(81)108(171)66(114)26-18-44-118-112(116)117/h10-15,22-25,31-34,56-61,66-81,89-90,140-141H,16-21,26-30,35-55,113-114H2,1-9H3,(H2,115,142)(H,119,157)(H,120,143)(H,121,158)(H,122,165)(H,123,155)(H,124,154)(H,125,163)(H,126,164)(H,127,169)(H,128,159)(H,129,166)(H,130,167)(H,131,156)(H,132,170)(H,133,160)(H,134,161)(H,135,162)(H,136,168)(H,144,145)(H,146,147)(H,148,149)(H,150,151)(H,152,153)(H,174,175)(H4,116,117,118)/t59-,60-,61-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,89-,90-/m0/s1
InChi Key
ZYDMZKPAPSZILB-WKNDHWIVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $120

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    1 mg

    $227

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    2.5 mg

    $442

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    Product Description

    Adrenocorticotropic hormone (ACTH) (18-39) is a C-terminal peptide fragment of ACTH, a peptide hormone found in the brain that is involved in the biological stress response.1 It is produced via processing of ACTH in the intermediate lobe of the pituitary gland.1,2 ACTH (18-39) increases cumulative food intake in fasted, but not fed, rats when administered intracerebroventricularly at a dose of 2.5 nmol/animal.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Strand, F.L., Lee, S.J., Zuccarelli, L.A., et al. Non-corticotropic ACTH peptides modulate nerve development and regeneration. Rev. Neurosci. 4(4), 321-363 (1993).

    2. Al-Barazanji, K.A., Miller, J.E., Rice, S.Q.J., et al. C-terminal fragments of ACTH stimulate feeding in fasted rats. Horm. Metab. Res. 33(8), 480-485 (2001).