An arginase inhibitor
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CB-1158 analog (hydrochloride)

Item No. 27297

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-amino-α-(4-boronobutyl)-1-[(2,4-dichlorophenyl)methyl]-4-piperidineacetic acid, dihydrochloride
CAS Number
1345672-75-4
Synonyms
  • INCB 01158 analog
  • Numidargistat analog
Molecular Formula
C18H27BCl2N2O4 • 2HCl
Formula Weight
454.6
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
ClC1=CC(Cl)=CC=C1C[NH+]2CCC(C(C(O)=O)([NH3+])CCCCB(O)O)CC2.[Cl-].[Cl-]
InChi Code
InChI=1S/C18H27BCl2N2O4.2ClH/c20-15-4-3-13(16(21)11-15)12-23-9-5-14(6-10-23)18(22,17(24)25)7-1-2-8-19(26)27;;/h3-4,11,14,26-27H,1-2,5-10,12,22H2,(H,24,25);2*1H
InChi Key
SLEDMEHPYLIMGX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Cayman Chemical
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    Product Description

    CB-1158 analog is an inhibitor of arginase I and II (IC50s = 0.086 and 0.296 µM for the human enzymes, respectively).1 It is selective for arginase I and II over neuronal nitric oxide synthase (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS; IC50s = >50 µM for all). CB-1158 analog reverses inhibition of T cell proliferation induced by granulocytes in vitro (IC50 = 0.204 µM). It reduces tumor growth in a CT26 murine colon cancer model when administered at a dose of 100 mg/kg twice per day.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Steggerda, S.M., Bennett, M.K., Chen, J., et al. Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment. J. Immunother. Cancer 5(1), 101 (2017).