An active metabolite of procainamide
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Acecainide (hydrochloride)

Item No. 27312

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(acetylamino)-N-[2-(diethylamino)ethyl]-benzamide, monohydrochloride
CAS Number
34118-92-8
Synonyms
  • N-Acetylprocainamide
Molecular Formula
C15H23N3O2 • HCl
Formula Weight
313.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 14 mg/mlEthanol: 16 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
272 nm
SMILES
CC(NC1=CC=C(C(NCCN(CC)CC)=O)C=C1)=O.Cl
InChi Code
InChI=1S/C15H23N3O2.ClH/c1-4-18(5-2)11-10-16-15(20)13-6-8-14(9-7-13)17-12(3)19;/h6-9H,4-5,10-11H2,1-3H3,(H,16,20)(H,17,19);1H
InChi Key
IYEWBJUCJHKLHD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

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    Product Description

    Acecainide is an active metabolite of the class III antiarrhythmic procainamide.1 It is formed from procainamide via hepatic N-acetyltransferases.2 Acecainide prevents hypoxia-induced ventricular fibrillation in mice and decreases arrhythmia induced by aconitine in dogs.1 Acecainide (10 µM), when used in high-fat medium, decreases lipid droplet area by greater than 50% in SK-Hep1 cells without inducing cytotoxicity but does not affect lipid droplets in primary mouse hepatocytes.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Drayer, D.E., Reidenberg, M.M., and Sevy, R.W. N-Acetylprocainamide. Active metabolite of procainamide. Proc. Soc. Exp. Biol. Med. 146(2), 358-363 (1974).

    2. Woosley, R.L., Drayer, D.E., Reidenberg, M.M., et al. Effect of acetylator phenotype on the rate at which procainamide induces antinuclear antibodies and the lupus syndrome. N. Engl. J. Med. 298(21), 1157-1159 (1978).

    3. Luo, W.-J., Cheng, T.-Y., Wong, K.-I., et al. Novel therapeutic drug identification and gene correlation for fatty liver disease using high-content screening: Proof of concept. Eur. J. Pharm. Sci. 121, 106-117 (2018).