A prodrug form of CNDAC
Related Products
Active Metabolite(s)
40672CNDAC (hydrochloride)
Technical Support & Resources

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Sapacitabine

Item No. 27321

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[1-(2-cyano-2-deoxy-b-D-arabinofuranosyl)-1,2-dihydro-2-oxo-4-pyrimidinyl]-hexadecanamide
CAS Number
151823-14-2
Synonyms
  • CS 682
  • CYC-682
Molecular Formula
C26H42N4O5
Formula Weight
490.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/ml
SMILES
O=C1N([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2C#N)C=CC(NC(CCCCCCCCCCCCCCC)=O)=N1
InChi Code
InChI=1S/C26H42N4O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-23(32)28-22-16-17-30(26(34)29-22)25-20(18-27)24(33)21(19-31)35-25/h16-17,20-21,24-25,31,33H,2-15,19H2,1H3,(H,28,29,32,34)/t20?,21-,24+,25-/m1/s1
InChi Key
LBGFKUUHOPIEMA-HFPBRLNESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $76

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    10 mg

    $137

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    25 mg

    $247

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    50 mg

    $418

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    Cayman Chemical
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    Product Description

    Sapacitabine is a prodrug form of the nucleoside derivative CNDAC (Item No. 40672).1 In vivo, sapacitabine (5 and 15 mg/kg) reduces tumor volume in an MV4-11 mouse xenograft model when administered alone or in combination with the histone deacetylase (HDAC) inhibitor SAHA (vorinostat; Item No. 10009929).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Green, S.R., Choudhary, A.K., and Fleming, I.N. Combination of sapacitabine and HDAC inhibitors stimulates cell death in AML and other tumour types. Br. J. Cancer 103(9), 1391-1399 (2010).