An inhibitor of autophagy
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Lys05 (hydrochloride)

Item No. 27334

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2-(7-chloro-4-quinolinyl)-N1-[2-[(7-chloro-4-quinolinyl)amino]ethyl]-N1-methyl-1,2-ethanediamine, trihydrochloride
CAS Number
1391426-24-6
Synonyms
  • Lys01
Molecular Formula
C23H23Cl2N5 • 3HCl
Formula Weight
549.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 2 mg/mlEthanol: Partially solublePBS (pH 7.2): Partially soluble
λmax
221, 257, 292, 331, 344 nm
SMILES
ClC1=CC2=NC=CC(NCCN(C)CCNC3=CC=NC4=C3C=CC(Cl)=C4)=C2C=C1.Cl.Cl.Cl
InChi Code
InChI=1S/C23H23Cl2N5.3ClH/c1-30(12-10-28-20-6-8-26-22-14-16(24)2-4-18(20)22)13-11-29-21-7-9-27-23-15-17(25)3-5-19(21)23;;;/h2-9,14-15H,10-13H2,1H3,(H,26,28)(H,27,29);3*1H
InChi Key
JTUYDBHQGOZPQQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $63

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    10 mg

    $110

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    25 mg

    $229

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    50 mg

    $396

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    Cayman Chemical
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    Product Description

    Lys05 is an inhibitor of autophagy.1 It induces p62 accumulation and increases the ratio of LC3-II to LC3-I in C8161 melanoma cells in a concentration-dependent manner. Lys05 (76 mg/kg) increases the number of autophagic vesicles per cell in tumors in a C8161 mouse xenograft model and reduces tumor volume and growth in a 1205Lu melanoma mouse xenograft model. It also reduces tumor growth rate, volume, and weight in an HT-29 colon cancer mouse xenograft model when administered at doses greater than or equal to 10 mg/kg but increases bowel thickness and obstruction when administered at 80 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McAfee, Q., Zhang, Q., Samanta, A., et al. Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency. Proc. Natl. Acad. Sci. USA 109(21), 8253-8258 (2012).