An inducer of Aβ42
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Aftin-4

Item No. 27341

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2R-[[9-(1-methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol
CAS Number
866893-90-5
Molecular Formula
C20H28N6O
Formula Weight
368.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
CC(C)N1C2=NC(N[C@@H](CO)CC)=NC(N(C)CC3=CC=CC=C3)=C2N=C1
InChi Code
InChI=1S/C20H28N6O/c1-5-16(12-27)22-20-23-18(25(4)11-15-9-7-6-8-10-15)17-19(24-20)26(13-21-17)14(2)3/h6-10,13-14,16,27H,5,11-12H2,1-4H3,(H,22,23,24)/t16-/m1/s1
InChi Key
YPYWONAECUVKHY-MRXNPFEDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    Aftin-4 is an inducer of amyloid-β (1-42) (Aβ42).1 It selectively increases extracellular Aβ42 over Aβ40 production in N2a-AβPP695 cells when used at concentrations ranging from 1 to 100 mM. In vivo, aftin-4 (3-20 nmol/animal, i.c.v.) increases hippocampal Aβ42 content, lipid peroxidation, and production of the pro-inflammatory cytokines IL-1β, IL-6, and TNF-α in mice.2 It also induces spatial working and spatial reference memory deficits in mice, effects that are reversed by co-administration of the γ-secretase inhibitor BMS-299,897.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hochard, A., Oumata, N., Bettayeb, K., et al. Aftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: Toward a chemical model of Alzheimer’s disease? J. Alzheim. Dis. 35(1), 107-120 (2013).

    2. Meunier, J., Borjini, N., Gillis, C.N., et al. Brain toxicity and inflammation induced in vivo in mice by the amyloid-β forty-two inducer aftin-4, a roscovitine derivative. J. Alzheim. Dis. 44(2), 507-524 (2015).