GPR99 (C-Term) Polyclonal Antibody

GPR99 is a G protein-coupled receptor (GPCR) that was originally identified as a purinergic receptor, P2Y15.^1,2 However, it is activated by leukotriene E₄ (LTE₄; Item No. 20410) in the low nanomolar range and by α-ketoglutarate in the high micromolar range.^3,4 It is found in the CNS, kidney, epididymis, and other tissues in the mouse, as well as in human kidney, nasal turbinates, and lung, among other tissues.^5,6 GPR99 knockout in mice prevents vascular leakage induced by LTE₄ and epithelial cell mucin release in mouse nasal mucosa induced by LTE₄ or A. alternata.³ In the kidney, under acid-base stress, it is involved with the regulation of carbonic acid and sodium chloride resorption through activation by α-ketoglutarate.⁵ GPR99 is also expressed in mouse retina, and axon growth is increased when it is activated by α-ketoglutarate in isolated mouse embryo retinal explants.⁷ Cayman’s GPR99 (C-Term) Polyclonal Antibody can be used for Western blot and immunohistochemistry (IHC) applications. The antibody recognizes the C-terminus of GPR99 from human samples.

WARNING This product is not for human or veterinary use.

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