An anthelmintic
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Pyrantel (pamoate)

Item No. 27368

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4'-methylenebis[3-hydroxy-2-naphthalenecarboxylic acid compd. with 1,4,5,6-tetrahydro-1-methyl-2-[(1E)-2-(2-thienyl)ethenyl]pyrimidine (1:1)
CAS Number
22204-24-6
Synonyms
  • CP 10423-16
Molecular Formula
C23H16O6 • C11H14N2S
Formula Weight
594.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
λmax
238, 290, 302 nm
SMILES
CN1CCCN=C1/C=C/C2=CC=CS2.OC(C3=CC(C=CC=C4)=C4C(CC5=C(O)C(C(O)=O)=CC6=C5C=CC=C6)=C3O)=O
InChi Code
InChI=1S/C23H16O6.C11H14N2S/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;1-13-8-3-7-12-11(13)6-5-10-4-2-9-14-10/h1-10,24-25H,11H2,(H,26,27)(H,28,29);2,4-6,9H,3,7-8H2,1H3/b;6-5+
InChi Key
AQXXZDYPVDOQEE-MXDQRGINSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Pyrantel is an anthelmintic and agonist of nematode nicotinic acetylcholine receptors (nAChRs).1,2,3 It activates chimeric C. elegans α7-nAChRs expressed in BOSC cells (EC50 = 40 μM) and induces contraction of A. suum muscle (EC50 = 57.5 nM).1,2 In vitro, pyrantel decreases survival of A. ceylanicum, N. americanus, and T. muris third-stage larvae (IC50s = 90.9, 2, and 95.5 μg/ml, respectively) and N. americanus and T. muris adults (IC50s = 7.6 and 34.1 μg/ml, respectively).3 In vivo, it decreases intestinal A. ceylanicum burden in hamsters and intestinal H. bakeri burden in mice when administered at a dose of 6 mg/kg.4 Formulations containing pyrantel have been used in the treatment of parasitic worm infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bartos, M., Rayes, D., and Bouzat, C. Molecular determinants of pyrantel selectivity in nicotinic receptors. Mol. Pharmacol. 70(4), 1307-1318 (2006).

    2. Martin, R.J., Clark, C.L., Trailovic, S.M., et al. Oxantel is an N-type (methyridine and nicotine) agonist not an L-type (levamisole and pyrantel) agonist: Classification of cholinergic anthelmintics in Ascaris. Int. J. Parasitol. 4(9), 1083-1090 (2004).

    3. Tritten, L., Silbereisen, A., and Keiser, J. In vitro and in vivo efficacy of Monepantel (AAD 1566) against laboratory models of human intestinal nematode infections. PLoS Negl. Trop. Dis. 5(12), e1457 (2011).

    4. Hu, Y., Ellis, B.L., Yiu, Y.Y., et al. An extensive comparison of the effect of anthelmintic classes on diverse nematodes. PLoS One 8(7), e70702 (2013).