A Bcl-xL inhibitor
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A-1155463

Item No. 27369

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluorophenoxy]propyl]-4-thiazolecarboxylic acid
CAS Number
1235034-55-5
Molecular Formula
C35H32FN5O4S2
Formula Weight
669.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
252, 292 nm
SMILES
CN(C)CC#CC1=CC=C(OCCCC2=C(C(O)=O)N=C(N3CC(C(C(NC4=NC5=C(C=CC=C5)S4)=O)=CC=C6)=C6CC3)S2)C(F)=C1
InChi Code
InChI=1S/C35H32FN5O4S2/c1-40(2)17-6-8-22-14-15-28(26(36)20-22)45-19-7-13-30-31(33(43)44)38-35(47-30)41-18-16-23-9-5-10-24(25(23)21-41)32(42)39-34-37-27-11-3-4-12-29(27)46-34/h3-5,9-12,14-15,20H,7,13,16-19,21H2,1-2H3,(H,43,44)(H,37,39,42)
InChi Key
SOYCFODXNRVBTI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    A-1155463 is an inhibitor of Bcl-xL (Ki = <0.01 nM).1 It is selective for Bcl-xL over Bcl-2 and Bcl-W (Kis = 80 and 16 nM, respectively). A-1155463 inhibits the growth of H146 small cell lung cancer cells (EC50 = 65 nM). In vivo, A-1155463 (5 mg/kg, i.p.) reduces tumor volume in an H146 mouse xenograft model. A-1155463 also induces premature apoptosis in influenza A-infected cells (EC50 = <10 nM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tao, Z.-F., Hasvold, L., Wang, L., et al. Discovery of a potent and selective BCL-XL inhibitor with in vivo activity. ACS Med. Chem. Lett. 5(10), 1088-1093 (2014).

    2. Bulanova, D., Ianevski, A., Bugai, A., et al. Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteins. Viruses 9(10), E271 (2017).