A peptide fragment of ACTH
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ACTH (6-24) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

Item No. 27403

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α6-24-corticotropin, trifluoroacetate salt
Synonyms
  • HFRWGKPVGKKRRPVKVYP
Molecular Formula
C111H175N35O21 • XCF3COOH
Formula Weight
2335.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(N[C@@H](CCCCN)C(N1CCC[C@H]1C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N2CCC[C@H]2C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@H](C(N3CCC[C@H]3C(O)=O)=O)CC4=CC=C(O)C=C4)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC5=CNC6=C5C=CC=C6)=O)=O)CC7=CC=CC=C7)=O)CC8=CN=CN8.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C111H175N35O21.C2HF3O2/c1-63(2)89(142-100(158)84-37-23-51-144(84)105(163)79(33-15-19-47-115)132-88(149)60-128-93(151)82(56-68-58-127-73-29-11-10-28-71(68)73)139-97(155)78(35-21-49-125-110(119)120)135-99(157)81(54-66-26-8-7-9-27-66)138-92(150)72(116)57-69-59-123-62-130-69)102(160)129-61-87(148)131-74(30-12-16-44-112)94(152)133-75(31-13-17-45-113)95(153)134-77(34-20-48-124-109(117)118)96(154)137-80(36-22-50-126-111(121)122)106(164)145-52-24-38-85(145)101(159)143-91(65(5)6)103(161)136-76(32-14-18-46-114)98(156)141-90(64(3)4)104(162)140-83(55-67-40-42-70(147)43-41-67)107(165)146-53-25-39-86(146)108(166)167;3-2(4,5)1(6)7/h7-11,26-29,40-43,58-59,62-65,72,74-86,89-91,127,147H,12-25,30-39,44-57,60-61,112-116H2,1-6H3,(H,123,130)(H,128,151)(H,129,160)(H,131,148)(H,132,149)(H,133,152)(H,134,153)(H,135,157)(H,136,161)(H,137,154)(H,138,150)(H,139,155)(H,140,162)(H,141,156)(H,142,158)(H,143,159)(H,166,167)(H4,117,118,124)(H4,119,120,125)(H4,121,122,126);(H,6,7)/t72-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,89-,90-,91-;/m0./s1
InChi Key
FGFORHXIYGTNES-DRJVTBINSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $79

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    Product Description

    ACTH (6-24) is a peptide fragment of adrenocorticotropic hormone (ACTH; Item No. 24257), a peptide hormone found in the brain that is involved in the biological stress response.1,2 ACTH (6-24) is a competitive inhibitor of steroidogenesis induced by ACTH (1-39) and ACTH (5-24) with mean Kd values of 13.4 and 3.4 nM, respectively.3 It also inhibits corticosterone production and cAMP accumulation induced by human parathyroid hormone (1-34) (Item No. 24985) when used at a concentration of 100 nM.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fauchère, J.-L., and Petermann, C. Synthesis and biological activity of four adrenocorticotropin‐(1‐24)‐tetracosapeptide analogues with N‐terminal deletions of four to seven amino‐acid residues. Helv. Chim. Acta. 61(3), 1186-1192 (1978).

    2. Strand, F.L., Lee, S.J., Zuccarelli, L.A., et al. Non-corticotropic ACTH peptides modulate nerve development and regeneration. Rev. Neurosci. 4(4), 321-363 (1993).

    3. Bristow, A.F., Gleed, C., Fauchère, J.L., et al. Effects of ACTH (corticotropin) analogues on steroidogenesis and cyclic AMP in rat adrenocortical cells. Evidence for two different steroidogenically responsive receptors. Biochem J. 186(2), 599-603 (1980).

    4. Rafferty, B.M., Zanelli, J.M., Rosenblatt, M.I., et al. Corticosteroidogenesis and adenosine 3', 5'- monophosphate production by the amino-terminal (1-34) fragment of human parathyroid hormone in rat adrenocortical cells. Endocrinology 113(3), 1036-1042 (1983).