A fluorescently labeled amyloid-β peptide
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TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt)

Item No. 27409

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • TAMRA-Aβ42
  • TAMRA-Aβ (1-42)
Molecular Formula
C228H331N57O64S • XCF3COOH
Formula Weight
4926.5
Purity
≥95%
Emission
572 nm
Excitation
543 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
O=C(O)C(F)(F)F.O=C(N([H])[C@H](C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@@H](CO)C(NCC(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(NCC(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@]([C@H](CC)C)([H])C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(NCC(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(O)=O)C)=O)=O)=O)=O)=O)=O)=O)CCSC)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)C)=O)CC1=CC=CC=C1)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)CC3=CN=CN3)=O)CC4=CN=CN4)=O)=O)=O)CC5=CC=C(O)C=C5)=O)=O)=O)CC(O)=O)=O)CC6=CN=CN6)=O)=O)CC7=CC=CC=C7)=O)=O)C)=O)CC(O)=O)C8=CC(C([O-])=O)=C(C9=C(C=C/%10)C(OC%11=C9C=CC(N(C)C)=C%11)=CC%10=[N+](C)/C)C=C8
InChi Code
InChI=1S/C228H331N57O64S.C2HF3O2/c1-32-119(20)187(219(338)244-104-171(294)252-149(81-111(4)5)205(324)262-148(76-80-350-31)202(321)276-181(113(8)9)217(336)242-100-168(291)239-101-173(296)275-183(115(12)13)222(341)280-186(118(18)19)223(342)283-188(120(21)33-2)224(343)251-125(26)226(345)346)282-225(344)189(121(22)34-3)281-192(311)122(23)248-169(292)102-240-194(313)141(55-44-46-77-229)257-212(331)158(93-167(232)290)269-216(335)163(107-287)254-172(295)105-243-218(337)182(114(10)11)277-215(334)161(96-179(307)308)270-200(319)146(70-74-175(299)300)256-190(309)123(24)249-203(322)152(83-126-49-38-35-39-50-126)266-208(327)154(85-128-53-42-37-43-54-128)272-220(339)185(117(16)17)279-214(333)150(82-112(6)7)264-196(315)142(56-45-47-78-230)258-198(317)144(68-72-166(231)289)260-209(328)155(88-131-97-235-108-245-131)268-211(330)157(90-133-99-237-110-247-133)273-221(340)184(116(14)15)278-201(320)147(71-75-176(301)302)261-206(325)151(86-129-58-63-136(288)64-59-129)253-170(293)103-241-195(314)162(106-286)274-213(332)160(95-178(305)306)271-210(329)156(89-132-98-236-109-246-132)267-197(316)143(57-48-79-238-228(233)234)259-207(326)153(84-127-51-40-36-41-52-127)265-199(318)145(69-73-174(297)298)255-191(310)124(25)250-204(323)159(94-177(303)304)263-193(312)130-60-65-137(140(87-130)227(347)348)180-138-66-61-134(284(27)28)91-164(138)349-165-92-135(285(29)30)62-67-139(165)180;3-2(4,5)1(6)7/h35-43,49-54,58-67,87,91-92,97-99,108-125,141-163,181-189,286-287H,32-34,44-48,55-57,68-86,88-90,93-96,100-107,229-230H2,1-31H3,(H61-,231,232,233,234,235,236,237,238,239,240,241,242,243,244,245,246,247,248,249,250,251,252,253,254,255,256,257,258,259,260,261,262,263,264,265,266,267,268,269,270,271,272,273,274,275,276,277,278,279,280,281,282,283,288,289,290,291,292,293,294,295,296,297,298,299,300,301,302,303,304,305,306,307,308,309,310,311,312,313,314,315,316,317,318,319,320,321,322,323,324,325,326,327,328,329,330,331,332,333,334,335,336,337,338,339,340,341,342,343,344,345,346,347,348);(H,6,7)/t119-,120-,121-,1
InChi Key
KAFBZLGUJZCQTJ-HOOHGBFQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $796

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    Product Description

    TAMRA-Amyloid-β (1-42) peptide is a fluorescently labeled peptide. Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-residue protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer’s disease.1,2 Aggregation of Aβ42 results in the formation of neurotoxic fibrils or globular oligomers.1 TAMRA-Amyloid-β (1-42) peptide is a labeled form of Aβ42 containing carboxytetramethyl rhodamine (TAMRA), which displays excitation/emission maxima of 543/572 nm, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wolfe, M.S. Therapeutic strategies for Alzheimer’s disease. Nat. Rev. Drug Discov. 1(11), 859-866 (2002).

    2. Iwatsubo, T., Odaka, A., Suzuki, N., et al. Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43). Neuron 13(1), 45-53 (1994).