A peptide fragment of amyloid-β
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Glp-Amyloid-β (3-40) Peptide (human) (trifluoroacetate salt)

Item No. 27416

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-oxo-L-prolyl-L-phenylalanyl-L-arginyl-L-histidyl-L-α-aspartyl-L-serylglycyl-L-tyrosyl-L-α-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-α-glutamyl-L-α-aspartyl-L-valylglycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionyl-L-valylglycylglycyl-L-valyl-L-valine, trifluoroacetate salt
Synonyms
  • AβN3(pE)-40
  • AβpE3-40
  • Glp-FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Molecular Formula
C187H283N51O53S • XCF3COOH
Formula Weight
4125.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
O=C(O)C(F)(F)F.O=C(N([H])[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@@H](CO)C(NCC(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(NCC(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@]([C@H](CC)C)([H])C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(NCC(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(O)=O)=O)=O)=O)=O)=O)CCSC)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)C)=O)CC1=CC=CC=C1)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)CC3=CN=CN3)=O)CC4=CN=CN4)=O)=O)=O)CC5=CC=C(O)C=C5)=O)=O)=O)CC(O)=O)=O)CC6=CN=CN6)=O)=O)CC7=CC=CC=C7)[C@@H]8CCC(N8)=O
InChi Code
InChI=1S/C187H283N51O53S.C2HF3O2/c1-24-100(19)153(181(285)203-85-140(248)210-120(66-92(3)4)167(271)219-119(61-65-292-23)165(269)232-147(94(7)8)179(283)201-81-137(245)198-82-142(250)231-149(96(11)12)184(288)236-152(99(17)18)186(290)291)238-185(289)154(101(20)25-2)237-156(260)102(21)207-138(246)83-199-157(261)112(46-35-37-62-188)214-174(278)129(75-135(191)243)225-178(282)133(88-240)212-141(249)86-202-180(284)148(95(9)10)233-177(281)131(77-146(257)258)226-163(267)117(55-59-143(251)252)213-155(259)103(22)208-166(270)123(68-104-40-29-26-30-41-104)222-170(274)125(70-106-44-33-28-34-45-106)228-182(286)151(98(15)16)235-176(280)121(67-93(5)6)220-159(263)113(47-36-38-63-189)215-162(266)116(53-57-134(190)242)217-171(275)126(72-108-78-194-89-204-108)224-173(277)128(74-110-80-196-91-206-110)229-183(287)150(97(13)14)234-164(268)118(56-60-144(253)254)218-168(272)122(71-107-49-51-111(241)52-50-107)211-139(247)84-200-158(262)132(87-239)230-175(279)130(76-145(255)256)227-172(276)127(73-109-79-195-90-205-109)223-160(264)114(48-39-64-197-187(192)193)216-169(273)124(69-105-42-31-27-32-43-105)221-161(265)115-54-58-136(244)209-115;3-2(4,5)1(6)7/h26-34,40-45,49-52,78-80,89-103,112-133,147-154,239-241H,24-25,35-39,46-48,53-77,81-88,188-189H2,1-23H3,(H2,190,242)(H2,191,243)(H,194,204)(H,195,205)(H,196,206)(H,198,245)(H,199,261)(H,200,262)(H,201,283)(H,202,284)(H,203,285)(H,207,246)(H,208,270)(H,209,244)(H,210,248)(H,211,247)(H,212,249)(H,213,259)(H,214,278)(H,215,266)(H,216,273)(H,217,275)(H,218,272)(H,219,271)(H,220,263)(H,221,265)(H,222,274)(H,223,264)(H,224,277)(H,225,282)(H,226,267)(H,227,276)(H,228,286)(H,229,287)(H,230,279)(H,231,250)(H,232,269)(H,233,281)(H,234,268)(H,235,280)(H,236,288)(H,237,260)(H,238,289)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,290,291)(H4,192,193,197);(H,6,7)/t100-,101-,102-,103-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,147-,148-,149-,150-,151-,152-,153-,154-;/m0./s1
InChi Key
KREKHHGEZSLQTD-WOGBONIYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    100 µg

    $902

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    Product Description

    Glp-Amyloid-β (3-40) peptide is a fragment of amyloid-β (1-40) (Aβ40; Item No. 21617) that contains the cyclic amino acid pyroglutamate at the N-terminus. Glp-Amyloid-β (3-40) peptide is a major component of the endogenous amyloid-β content in post-mortem brain tissue from patients with Alzheimer’s disease.1 It is formed through cleavage of the N-terminal aspartate and alanine on Aβ40 and Aβ42 followed by dehydration of glutamic acid by glutaminyl cyclase.2 Glp-Amyloid-β (3-40) peptide has been used as a reference peptide for the quantification of total pyroglutamate amyloid-β in APP23 mouse brain.1

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    References & Product Citations
    Product Description References

    1. Schieb, H., Kratzin, H., Jahn, O., et al. β-Amyloid peptide variants in brains and cerebrospinal fluid from amyloid precursor protein (APP) transgenic mice. Comparison with human Alzheimer amyloid. The Journal of Biological Chemisty 286(39), 33747-33758 (2011).

    2. Jawhar, S., Wirths, O., and Bayer, T.A. Pyroglutamate amyloid-β (Aβ): A hatchet man in Alzheimer disease. The Journal of Biological Chemisty 286(45), 38825-38832 (2011).