A 15-residue cyclized APP fragment
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Amyloid-β Precursor Protein (96-110) Peptide (cyclized) (human) (trifluoroacetate salt)

Item No. 27419

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2-acetyl-L-asparaginyl-L-tryptophyl-L-cysteinyl-L-lysyl-L-arginylglycyl-L-arginyl-L-lysyl-L-glutaminyl-L-cysteinyl-L-lysyl-L-threonyl-L-histidyl-L-prolyl-L-histidinamide cyclic (3→10)-disulfide, trifluoroacetate salt
Synonyms
  • Cyclized APP (96-110)
  • Cyclized APP96-110
Molecular Formula
C81H128N32O19S2 • XCF3COOH
Formula Weight
1918.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
O=C(O)C(F)(F)F.NC([C@@H](NC([C@@H]1CCCN1C([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](CCCCN)NC([C@@H](N2)CSSC[C@H](NC([C@@H](NC([C@H](CC(N)=O)NC(C)=O)=O)CC3=CNC4=C3C=CC=C4)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C2=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC5=CN=CN5)=O)=O)CC6=CN=CN6)=O
InChi Code
InChI=1S/C81H128N32O19S2.C2HF3O2/c1-42(114)65(78(131)109-58(32-46-36-93-41-99-46)79(132)113-29-13-21-61(113)77(130)107-55(66(87)119)31-45-35-92-40-98-45)112-72(125)53(18-7-10-26-84)105-75(128)59-38-133-134-39-60(111-73(126)56(30-44-34-96-48-15-4-3-14-47(44)48)108-74(127)57(33-63(86)117)100-43(2)115)76(129)104-52(17-6-9-25-83)69(122)102-49(19-11-27-94-80(88)89)67(120)97-37-64(118)101-50(20-12-28-95-81(90)91)68(121)103-51(16-5-8-24-82)70(123)106-54(71(124)110-59)22-23-62(85)116;3-2(4,5)1(6)7/h3-4,14-15,34-36,40-42,49-61,65,96,114H,5-13,16-33,37-39,82-84H2,1-2H3,(H2,85,116)(H2,86,117)(H2,87,119)(H,92,98)(H,93,99)(H,97,120)(H,100,115)(H,101,118)(H,102,122)(H,103,121)(H,104,129)(H,105,128)(H,106,123)(H,107,130)(H,108,127)(H,109,131)(H,110,124)(H,111,126)(H,112,125)(H4,88,89,94)(H4,90,91,95);(H,6,7)/t42-,49+,50+,51+,52+,53+,54+,55+,56+,57+,58+,59+,60+,61+,65+;/m1./s1
InChi Key
FCBNWKRNNPYNAS-ZXNSTZMFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $112

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    1 mg

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    Product Description

    Amyloid-β precursor protein (96-110) peptide (cyclized) is a synthetic peptide consisting of amino acids 96-110 of amyloid precursor peptide (APP) that is cyclized via a bridge between the cysteine residues at positions 3 and 10.1 It is homologous to the heparin-binding domain of human APP and inhibits binding of [125I]APP to heparin in vitro with an IC50 value of approximately 100 nM. Amyloid-β precursor protein (96-110) peptide (cyclized) inhibits neurite outgrowth induced by APP and mouse postnatal heparan sulfate proteoglycans (HSPG) in primary mouse hippocampal neurons when used at a concentration of 10 μg/ml.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Small, D.H., Nurcombe, V., Reed, G., et al. A heparin-binding domain in the amyloid protein precursor of Alzheimer’s disease is involved in the regulation of neurite outgrowth. J. Neurosci. 14(4), 2117-2127 (1994).