A caspase-1/ICE inhibitor
Related Products
Alternative(s)
10016Ac-YVAD-CHO
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YVAD-CHO (trifluoroacetate salt)

Item No. 27420

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-tyrosyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]-L-alaninamide, trifluoroacetate salt
Synonyms
  • H-Tyr-Val-Ala-Asp-CHO
Molecular Formula
C21H30N4O7 • XCF3COOH
Formula Weight
450.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
OC1=CC=C(C[C@H](N)C(N[C@H](C(N[C@@H](C)C(N[C@H](C=O)CC(O)=O)=O)=O)C(C)C)=O)C=C1.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C21H30N4O7.C2HF3O2/c1-11(2)18(25-20(31)16(22)8-13-4-6-15(27)7-5-13)21(32)23-12(3)19(30)24-14(10-26)9-17(28)29;3-2(4,5)1(6)7/h4-7,10-12,14,16,18,27H,8-9,22H2,1-3H3,(H,23,32)(H,24,30)(H,25,31)(H,28,29);(H,6,7)/t12-,14-,16-,18-;/m0./s1
InChi Key
WCANZHRQONOARC-PNMKJZCWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    YVAD-CHO is an inhibitor of caspase-1/interleukin-1β converting enzyme (ICE) and a non-acetylated form of Ac-YVAD-CHO (Item No. 10016).1 It prevents ICE-like and CPP32-like proteinase activity and inhibits apoptosis induced by ceramide or irinotecan (CPT-11; Item No. 14180) in 4B1 cells when used at a concentration of 600 µM. YVAD-CHO (100 µM) also prevents chromogranin A-induced cell death of primary rat microglia but not primary rat cerebellar granule neurons.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Suzuki, A., Iwasaki, M., Kato, M., et al. Sequential operation of ceramide synthesis and ICE cascade in CPT-11-initiated apoptotic death signaling. Exp. Cell Res. 233(1), 41-47 (1997).

    2. Kingham, P.J., Cuzner, M.L., and Pocock, J.M. Apoptotic pathways mobilized in microglia and neurones as a consequence of chromogranin A-induced microglial activation. J. Neurochem. 73(2), 538-547 (1999).