A pan-caspase inhibitor
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Z-VA-DL-D(OMe)-FMK (trifluoroacetate salt)

Item No. 27421

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(phenylmethoxy)carbonyl]-L-valyl-N-[3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide, trifluoroacetate salt
Synonyms
  • Caspase-1 Inhibitor V
  • Z-VAD-FMK
  • Z-VAD(OMe)-FMK
  • Z-Val-Ala-DL-Asp(OMe)-Fluoromethyl Ketone
Molecular Formula
C22H30FN3O7 • XCF3COOH
Formula Weight
467.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/mlFormic Acid: 1 mg/ml
SMILES
CC(C)[C@@H](C(N[C@@H](C)C(NC(CC(OC)=O)C(CF)=O)=O)=O)NC(OCC1=CC=CC=C1)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C22H30FN3O7.C2HF3O2/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4;3-2(4,5)1(6)7/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31);(H,6,7)/t14-,16?,19-;/m0./s1
InChi Key
AJFONZVLSMNYOS-YOJUQOAVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $82

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    1 mg

    $154

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    Product Description

    Z-VA-DL-D(OMe)-FMK (Z-VAD-FMK) is a pan-caspase inhibitor.1 It inhibits anti-Fas antibody-induced cleavage of caspase-3 and PARP in Jurkat T lymphocytes when used at a concentration of 0.5 μM. Z-VAD-FMK (50 μM) inhibits cell death induced by TNF-α and cycloheximide co-application in HeLa cells. It also inhibits radiation-induced increases in the number of TUNEL-positive neurons in the rat hypoglossal nucleus when administered intracerebroventricularly at a dose of 2 μg per animal.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yang, W., Guastella, J., Huang, J.-C., et al. MX1013, a dipeptide caspase inhibitor with potent in vivo antiapoptotic activity. Br. J. Pharmacol. 140(2), 402-412 (2003).

    2. Li, J., Wang, Y., Du, L., et al. Radiation-induced cytochrome c release and the neuroprotective effects of the pan-caspase inhibitor z-VAD-fmk in the hypoglossal nucleus. Exp. Ther. Med. 7(2), 383-388 (2014).

    Product Citations

    Hendricks, J.M., Doubravsky, C., Wehri, E., et al. Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis. Cell Chem. Biol. 30(9), P1090-P1103 (2022).

    Li, Z., Ferguson, L., Deol, K.K., et al. Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability. Nat. Chem. Biol. (2022).