A caspase-1 and caspase-4 fluorogenic substrate
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Alternative(s)
27424Ac-WEAD-pNA (trifluoroacetate salt)
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Ac-WEAD-AMC (trifluoroacetate salt)

Item No. 27423

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4S,7S,10S,13S)-4-((1H-indol-3-yl)methyl)-7-(2-carboxyethyl)-10-methyl-13-((4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl)-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid, trifluoroacetate salt
Synonyms
  • Ac-Trp-Glu-Ala-Asp-AMC
Molecular Formula
C35H38N6O11 • XCF3COOH
Formula Weight
718.7
Purity
≥95%
Emission
440-460 nm
Excitation
340-360 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
O=C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@H](C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(NC3=CC(OC(C=C4C)=O)=C4C=C3)=O)=O)=O)CCC(O)=O)=O)C.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C35H38N6O11.C2HF3O2/c1-17-12-31(47)52-28-14-21(8-9-22(17)28)39-34(50)27(15-30(45)46)41-32(48)18(2)37-33(49)25(10-11-29(43)44)40-35(51)26(38-19(3)42)13-20-16-36-24-7-5-4-6-23(20)24;3-2(4,5)1(6)7/h4-9,12,14,16,18,25-27,36H,10-11,13,15H2,1-3H3,(H,37,49)(H,38,42)(H,39,50)(H,40,51)(H,41,48)(H,43,44)(H,45,46);(H,6,7)/t18-,25-,26-,27-;/m0./s1
InChi Key
ZCRDADLKXGATGV-FRSNKCIVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $33

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    5 mg

    $156

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    Product Description

    Ac-WEAD-AMC is a fluorogenic substrate for caspase-1 and caspase-4.1 Upon enzymatic cleavage by caspase-1 or caspase-4, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify caspase-1 or caspase-4 activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, D., Adams, J.L., Brandt, M., et al. A substrate combinatorial array for caspases. Bioorg. Med. Chem. Lett. 9(12), 1667-1672 (1999).