A peptide fragment of ACTH
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ACTH (4-11) (human, mouse, rat, porcine, bovine, ovine)

Item No. 27430

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysine
CAS Number
67224-41-3
Synonyms
  • MEHFRWGK-OH
Molecular Formula
C50H71N15O11S
Formula Weight
1090.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10mg/mLDMSO: 10mg/mLPBS (pH 7.2): 10mg/mL
λmax
281 nm
SMILES
[H]N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(N[C@@H](CCCCN)C(O)=O)=O)=O)CC1=CNC2=C1C=CC=C2)=O)=O)CC3=CC=CC=C3)=O)CC4=CN=CN4)=O)=O)CCSC
InChi Code
InChI=1S/C50H71N15O11S/c1-77-21-18-33(52)43(69)61-36(16-17-42(67)68)46(72)65-40(24-31-26-55-28-59-31)48(74)63-38(22-29-10-3-2-4-11-29)47(73)62-35(15-9-20-56-50(53)54)45(71)64-39(23-30-25-57-34-13-6-5-12-32(30)34)44(70)58-27-41(66)60-37(49(75)76)14-7-8-19-51/h2-6,10-13,25-26,28,33,35-40,57H,7-9,14-24,27,51-52H2,1H3,(H,55,59)(H,58,70)(H,60,66)(H,61,69)(H,62,73)(H,63,74)(H,64,71)(H,65,72)(H,67,68)(H,75,76)(H4,53,54,56)/t33-,35-,36-,37-,38-,39-,40-/m0/s1
InChi Key
ZKBNJKUZBFBIKV-YJXWTMGESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $52

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    5 mg

    $151

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    10 mg

    $275

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    Product Description

    ACTH (4-11) is a peptide fragment of adrenocorticotropic hormone (ACTH; Item No. 24257), a peptide hormone found in the brain that is involved in the biological stress response.1 ACTH (4-11) induces differentiation of melanocytes when used at a concentration of 1,000 nM.2 It inhibits angiotensin converting enzyme (ACE) activity in homogenized canine lung with an IC50 value of 24 µM.3 ACTH (4-11) has been used to determine substrate specificity of recombinant H. zea carboxypeptidase B enzyme (CPBHz).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Strand, F.L., Lee, S.J., Zuccarelli, L.A., et al. Non-corticotropic ACTH peptides modulate nerve development and regeneration. Rev. Neurosci. 4(4), 321-363 (1993).

    2. Vatolin, S., Phillips, J.G., Jha, B.K., et al. Novel protein disulfide isomerase inhibitor with anticancer activity in multiple myeloma. Cancer Res. 76(11), 3340-3350 (2016).

    3. Verma, P.S., Miller, R.L., Taylor, R.E., et al. Inhibition of canine lung angiotensin converting enzyme by ACTH and structurally related peptides. Biochem. Biophys. Res. Commun. 104(4), 1484-1488 (1982).

    4. Bayés, A., Rodríguez de la Vega, M., Vendrell, J., et al. Response of the digestive system of Helicoverpa zea to ingestion of potato carboxypeptidase inhibitor and characterization of an uninhibited carboxypeptidase B. Insect Biochem. Mol. Biol. 36(8), 654-664 (2006).