A caspase-4 inhibitor
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Ac-LEVD-CHO (trifluoroacetate salt)

Item No. 27433

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-L-leucyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-L-valinamide, trifluoroacetate salt
Synonyms
  • Ac-Leu-Glu-Val-Asp-CHO
  • Caspase-4 Inhibitor I
Molecular Formula
C22H36N4O9 • XCF3COOH
Formula Weight
500.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
CC(C)[C@@H](C(N[C@H](C=O)CC(O)=O)=O)NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC(C)C)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C22H36N4O9.C2HF3O2/c1-11(2)8-16(23-13(5)28)21(34)25-15(6-7-17(29)30)20(33)26-19(12(3)4)22(35)24-14(10-27)9-18(31)32;3-2(4,5)1(6)7/h10-12,14-16,19H,6-9H2,1-5H3,(H,23,28)(H,24,35)(H,25,34)(H,26,33)(H,29,30)(H,31,32);(H,6,7)/t14-,15-,16-,19-;/m0./s1
InChi Key
IOLOJOYPCDOFHT-LKGQOPIMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $95

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    5 mg

    $392

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    Cayman Chemical
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    Product Description

    Ac-LEVD-CHO is a caspase-4 inhibitor.1 It inhibits IL-1α expression and secretion and caspase-4 activation induced by the T. denticola periodontal pathogen surface protein Td92 in human gingival fibroblasts when used at a concentration of 30 μM. Ac-LEVD-CHO (10 μM) also reduces apoptosis induced by expression of the dominant negative adenoviral RNA-dependent protein kinase (Ad-Δ6PKR) in A549 and PC3 cancer cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jun, H.-K., Jung, Y.-J., An, S.-J., et al. Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts. Cell Death Differ. 25(2), 380-391 (2018).

    2. Pataer, A., Swisher, S.G., Roth, J.A., et al. Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity. Cancer Biol. Ther. 8(3), 245-252 (2009).