An inhibitor of caspase-1 and caspase-3
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Alternative(s)
10016Ac-YVAD-CHO
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Z-YVAD-CMK (trifluoroacetate salt)

Item No. 27435

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(phenylmethoxy)carbonyl]-L-tyrosyl-L-valyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-L-alaninamide, trifluoroacetate salt
Synonyms
  • Benxyloxycarbonyl-Tyr-Val-Ala-Asp-Chloromethylketone
  • Caspase-1 Inhibitor IV
Molecular Formula
C30H37ClN4O9 • XCF3COOH
Formula Weight
633.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/ml
SMILES
O=C([C@H](C)NC([C@H](C(C)C)NC([C@H](CC1=CC=C(O)C=C1)NC(OCC2=CC=CC=C2)=O)=O)=O)N[C@H](C(CCl)=O)CC(O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C30H37ClN4O9.C2HF3O2/c1-17(2)26(29(42)32-18(3)27(40)33-22(14-25(38)39)24(37)15-31)35-28(41)23(13-19-9-11-21(36)12-10-19)34-30(43)44-16-20-7-5-4-6-8-20;3-2(4,5)1(6)7/h4-12,17-18,22-23,26,36H,13-16H2,1-3H3,(H,32,42)(H,33,40)(H,34,43)(H,35,41)(H,38,39);(H,6,7)/t18-,22-,23-,26-;/m0./s1
InChi Key
VIEXXRMVRHEMFV-NWFMSPOZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Cayman Chemical
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    Product Description

    Z-YVAD-CMK is an inhibitor of caspase-1 and caspase-3.1,2 It reduces IL-1β and IL-18 secretion in isolated mouse peritoneal macrophages stimulated by cholesterol-treated recombinant pneumolysin protein (rPLY) when used at a concentration of 30 µM.1 Z-YVAD-CMK reduces caspase-3 activation by the EGF-like domain of tenascin-C in detached human smooth muscle cells (hSMCs) in vitro.2 It also decreases cell death induced by the EGF-like domain of tenascin-C by 50% when used at a concentration of 100 µM in hSMCs and completely inhibits cell death at concentrations ranging from 200 to 400 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shoma, S., Tsuchiya, K., Kawamura, I., et al. Critical involvement of pneumolysin in production of interleukin-1α and caspase-1-dependent cytokines in infection with Streptococcus pneumoniae in vitro: A novel function of pneumolysin in caspase-1 activation. Infect. Immun. 76(4), 1547-1557 (2008).

    2. Wallner, K., Li, C., Shah, P.K., et al. EGF-Like domain of tenascin-C is proapoptotic for cultured smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 24(8), 1416-1421 (2004).