A caspase-6 inhibitor
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Ac-VEID-CHO (trifluoroacetate salt)

Item No. 27437

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4S,7S,10S,13S)-10-((S)-sec-butyl)-7-(2-carboxyethyl)-13-formyl-4-isopropyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid, trifluoroacetate salt
Synonyms
  • Ac-Val-Glu-Ile-Asp-CHO
Molecular Formula
C22H36N4O9 • XCF3COOH
Formula Weight
500.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
OC(C[C@H](NC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@H](C(C)C)NC(C)=O)=O)CCC(O)=O)=O)=O)C=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C22H36N4O9.C2HF3O2/c1-6-12(4)19(22(35)24-14(10-27)9-17(31)32)26-20(33)15(7-8-16(29)30)25-21(34)18(11(2)3)23-13(5)28;3-2(4,5)1(6)7/h10-12,14-15,18-19H,6-9H2,1-5H3,(H,23,28)(H,24,35)(H,25,34)(H,26,33)(H,29,30)(H,31,32);(H,6,7)/t12-,14-,15-,18-,19-;/m0./s1
InChi Key
DMUVMYXFMMONRW-NVOIZEPQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $169

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    Product Description

    Ac-VEID-CHO is an inhibitor of caspase-6 (IC50 = 16.2 nM).1 It is selective for caspase-6 over caspase-7 (IC50 = 162.1 nM) but can also inhibit caspase-3 (IC50 = 13.6 nM). Ac-VEID-CHO (100 μM) inhibits ricin-induced caspase-6-, but not caspase-3-, like activity in U937 cells.2 It also inhibits caspase-6-like activity in Norway spruce cell extracts when used at a concentration of 2 μM, as well as in staurosporine-treated SKNAS neuroblastoma cells with an IC50 value of 0.49 μM.1,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mintzer, R., Ramaswamy, S., Shah, K., et al. A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C. PLoS One 7(1), e30376 (2012).

    2. Komatsu, N., Oda, T., and Muramatsu, T. Involvement of both caspase-like proteases and serine proteases in apoptotic cell death induced by ricin, modeccin, diphtheria toxin, and Pseudomonas toxin. J. Biochem. 124(5), 1038-1044 (1998).

    3. Bozhkov, P.V., Filonova, L.H., Suarez, M.F., et al. VEIDase is a principal caspase-like activity involved in plant programmed cell death and essential for embryonic pattern formation. Cell Death Differ. 11(2), 175-182 (2004).