An inhibitor of caspase-8 and granzyme B
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Ac-AAVALLPAVLLALLAP-IETD-CHO (trifluoroacetate salt)

Item No. 27438

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-L-alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-prolyl-L-isoleucyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-L-threoninamide, trifluoroacetate salt
Synonyms
  • Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-CHO
  • Caspase-8 Inhibitor I
Molecular Formula
C95H162N20O26 • XCF3COOH
Formula Weight
2000.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
CC(C)[C@@H](C(N[C@@H](C)C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@@H](C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C)C(N[C@H](C(N[C@H](C(N[C@@H](C)C(N2CCC[C@H]2C(N[C@]([H])(C(N[C@H](C(N[C@]([H])(C(N[C@@H](CC(O)=O)C=O)=O)[C@H](O)C)=O)CCC(O)=O)=O)[C@@H](C)CC)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)CC(C)C)=O)CC(C)C)=O)C(C)C)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)NC([C@H](C)NC([C@H](C)NC(C)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C95H162N20O26.C2HF3O2/c1-27-52(18)75(92(138)103-62(32-33-71(119)120)82(128)113-76(59(25)117)93(139)102-61(43-116)42-72(121)122)112-89(135)70-31-28-34-114(70)94(140)58(24)101-84(130)64(37-45(4)5)107-85(131)65(38-46(6)7)104-78(124)54(20)98-83(129)63(36-44(2)3)106-86(132)67(40-48(10)11)108-91(137)74(51(16)17)111-81(127)57(23)99-88(134)69-30-29-35-115(69)95(141)68(41-49(12)13)109-87(133)66(39-47(8)9)105-79(125)55(21)100-90(136)73(50(14)15)110-80(126)56(22)97-77(123)53(19)96-60(26)118;3-2(4,5)1(6)7/h43-59,61-70,73-76,117H,27-42H2,1-26H3,(H,96,118)(H,97,123)(H,98,129)(H,99,134)(H,100,136)(H,101,130)(H,102,139)(H,103,138)(H,104,124)(H,105,125)(H,106,132)(H,107,131)(H,108,137)(H,109,133)(H,110,126)(H,111,127)(H,112,135)(H,113,128)(H,119,120)(H,121,122);(H,6,7)/t52-,53-,54-,55-,56-,57-,58-,59+,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,73-,74-,75-,76-;/m0./s1
InChi Key
COGMWHXRSXGJMX-PWAYNZGCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    500 µg

    $112

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    1 mg

    $212

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    Cayman Chemical
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    Product Description

    Ac-AAVALLPAVLLALLAP-IETD-CHO is a composite of Ac-IETD-CHO (Item No. 27100), a peptide inhibitor of caspase-8, and a cell-permeable hydrophobic sequence derived from K-FGF.1,2 It is an inhibitor of both caspase-8 and granzyme B.1,3,4 It prevents death of SKOV3 ovarian carcinoma cells transfected with Survivin and granzyme B-induced apoptosis (SAGA) when used at a concentration of 20 µM.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Garcia-Calvo, M., Peterson, E.P., Leiting, B., et al. Inhibition of human caspases by peptide-based and macromolecular inhibitors. The Journal of Biological Chemisty 273(49), 32608-32613 (1998).

    2. Lin, Y.Z., Tao, S., Veach, R.A., et al. Inhibition of nuclear translocation of transcription factor NF-κB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. The Journal of Biological Chemisty 270(24), 14255-14258 (1995).

    3. Li, N., and Tan, W. Intelligent nanomedicine integrating diagnosis and therapy. US 8,257,918 B2, (2012).

    4. Caldas, H., Jaynes, F.O., Boyer, M.W., et al. Survivin and Granzyme B-induced apoptosis, a novel anticancer therapy. Mol. Cancer. Ther. 5(3), 693-703 (2006).