A peptide fragment of histone H2AX
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Histone H2AX (134-143) (human) (trifluoroacetate salt)

Item No. 27441

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-lysyl-L-lysyl-L-alanyl-L-threonyl-L-glutaminyl-L-alanyl-L-seryl-L-glutaminyl-L-α-glutamyl-L-tyrosine, trifluoroacetate salt
Synonyms
  • H-Lys-Lys-Ala-Thr-Gln-Ala-Ser-Gln-Glu-Tyr-OH
  • KKATQASQEY
Molecular Formula
C49H80N14O18 • XCF3COOH
Formula Weight
1153.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
OC(C(F)(F)F)=O.[H]N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(O)=O)CC1=CC=C(O)C=C1)=O)=O)=O)=O)C)=O)=O)=O)C)=O)=O
InChi Code
InChI=1S/C49H80N14O18.C2HF3O2/c1-24(40(71)62-35(23-64)47(78)59-32(15-18-37(54)68)45(76)58-33(16-19-38(69)70)46(77)61-34(49(80)81)22-27-10-12-28(66)13-11-27)55-44(75)31(14-17-36(53)67)60-48(79)39(26(3)65)63-41(72)25(2)56-43(74)30(9-5-7-21-51)57-42(73)29(52)8-4-6-20-50;3-2(4,5)1(6)7/h10-13,24-26,29-35,39,64-66H,4-9,14-23,50-52H2,1-3H3,(H2,53,67)(H2,54,68)(H,55,75)(H,56,74)(H,57,73)(H,58,76)(H,59,78)(H,60,79)(H,61,77)(H,62,71)(H,63,72)(H,69,70)(H,80,81);(H,6,7)/t24-,25-,26+,29-,30-,31-,32-,33-,34-,35-,39-;/m0./s1
InChi Key
CLTAABLSSFJIJQ-RVPSEXMLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $85

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    Product Description

    Histone H2AX (134-143) is a C-terminal peptide fragment of histone H2AX that corresponds to amino acid residues 134-143 of the human histone H2AX sequence. Histone H2AX (134-143) is an evolutionarily conserved motif that differentiates histone H2AX from other H2A histones.1 It contains a serine residue that is rapidly phosphorylated upon introduction of DNA double-strand breaks and initiation of DNA fragmentation during apoptosis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rogakou, E.P., Nieves-Neira, W., Boon, C., et al. Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139. The Journal of Biological Chemisty 275(13), 9390-9395 (2000).