An inhibitor of Wnt signaling
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Product Categories

Product Type

Biochemicals

Research Area

Cell Biology
Cell Signaling
Wnt Signaling

YW1159

Item No. 27451

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(2-fluorophenyl)-5-methyl-N-2-quinolinyl-1H-1,2,3-triazole-4-carboxamide
CAS Number
2131223-69-1
Synonyms
  • Compound 3d
Molecular Formula
C19H14FN5O
Formula Weight
347.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: 30 mg/mlDMF: 5 mg/mlDMF:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
257, 318, 332 nm
SMILES
O=C(C1=C(C)N(C2=C(F)C=CC=C2)N=N1)NC3=CC=C(C=CC=C4)C4=N3
InChi Code
InChI=1S/C19H14FN5O/c1-12-18(23-24-25(12)16-9-5-3-7-14(16)20)19(26)22-17-11-10-13-6-2-4-8-15(13)21-17/h2-11H,1H3,(H,21,22,26)
InChi Key
PNGUNLPOXKPCPK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $69

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    5 mg

    $313

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    10 mg

    $591

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    Product Description

    YW1159 is an inhibitor of Wnt signaling with an IC50 value of 1.2 nM in a reporter assay.1,2 It is not cytotoxic to HEK293 cells following incubations of up to 24 hours but cell viability is decreased in a concentration-dependent manner after 72 hours.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xue, F., and Shu, Y. Wnt signaling pathway inhibitors for treatments of disease. WO 2017/151786 Al, (2017).

    2. Obianom, O.N., Ai, Y., Li, Y., et al. Triazole-based inhibitors of the Wnt/β-catenin signaling pathway improve glucose and lipid metabolism in diet-induced obese mice. J. Med. Chem. 62(2), 727-741 (2019).