A p53 stabilizing agent
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CP 31,398 (hydrochloride)

Item No. 27455

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N3-[2-[2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]-N1,N1-dimethyl-1,3-propanediamine, dihydrochloride
CAS Number
1217195-61-3
Molecular Formula
C22H26N4O • 2HCl
Formula Weight
435.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 16 mg/mlEthanol: 2 mg/mlPBS (pH 7.2): 2.5 mg/ml
λmax
212, 245, 369 nm
SMILES
CN(C)CCCNC1=NC(/C=C/C2=CC=C(OC)C=C2)=NC3=C1C=CC=C3.Cl.Cl
InChi Code
InChI=1S/C22H26N4O.2ClH/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17;;/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25);2*1H/b14-11+;;
InChi Key
WWIFDJIOGCGSBS-IVKCLRODSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    Product Description

    CP 31,398 is a p53 stabilizing agent.1 It increases active mutant p53 and p53 reporter gene expression without increasing total protein levels of p53 in H1299 lung cancer cells transfected with mutant p53. CP 31,398 is cytotoxic to a panel of 12 human glioma cell lines expressing wild-type or mutant p53 (EC50s = 11.2-22.2 μM).2 In vivo, CP 31,398 (100 mg/kg) decreases tumor growth by 50% in an A375.S2 melanoma mouse xenograft model and completely inhibits tumor growth in a DLD-1 colon cancer mouse xenograft model.1 Dietary administration of CP 31,398 (50 and 100 ppm) suppresses lung adenocarcinoma formation in a mouse model of tobacco carcinogen-induced lung adenoma and adenocarcinoma formation.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Foster, B.A., Coffey, H.A., Morin, M.J., et al. Pharmacological rescue of mutant p53 conformation and function. Science 286(5449), 2507-2510 (1999).

    2. Wischhusen, J., Naumann, U., Ohgaki, H., et al. CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death. Oncogene 22(51), 8233-8245 (2003).

    3. Rao, C.V., Patlolla, J.M., Qian, L., et al. Chemopreventive effects of the p53-modulating agents CP-31398 and Prima-1 in tobacco carcinogen-induced lung tumorigenesis in A/J mice. Neoplasia 15(9), 1018-1027 (2013).