A peptide fragment of histone H2B
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Histone H2B (21-35) (human, mouse, rat, bovine) (trifluoroacetate salt)

Item No. 27472

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-alanyl-L-glutaminyl-L-lysyl-L-lysyl-L-aspartylglycyl-L-lysyl-L-lysyl-L-arginyl-L-lysyl-L-arginyl-L-seryl-L-arginyl-L-lysyl-L-glutamic acid, trifluoroacetate salt
Synonyms
  • AQKKDGKKRKRSRKE
  • AspH2B21-35
  • H2B21-35
Molecular Formula
C76H143N31O22 • XCF3COOH
Formula Weight
1843.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)C.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C76H143N31O22.C2HF3O2/c1-42(83)60(115)96-52(26-28-56(84)109)71(126)101-46(20-5-11-33-80)63(118)100-48(22-7-13-35-82)69(124)106-54(39-59(113)114)61(116)94-40-57(110)95-43(17-2-8-30-77)62(117)97-44(18-3-9-31-78)64(119)102-49(23-14-36-91-74(85)86)66(121)98-45(19-4-10-32-79)65(120)103-51(25-16-38-93-76(89)90)70(125)107-55(41-108)72(127)104-50(24-15-37-92-75(87)88)67(122)99-47(21-6-12-34-81)68(123)105-53(73(128)129)27-29-58(111)112;3-2(4,5)1(6)7/h42-55,108H,2-41,77-83H2,1H3,(H2,84,109)(H,94,116)(H,95,110)(H,96,115)(H,97,117)(H,98,121)(H,99,122)(H,100,118)(H,101,126)(H,102,119)(H,103,120)(H,104,127)(H,105,123)(H,106,124)(H,107,125)(H,111,112)(H,113,114)(H,128,129)(H4,85,86,91)(H4,87,88,92)(H4,89,90,93);(H,6,7)/t42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-;/m0./s1
InChi Key
FOHZKCCIWFZLSE-SUNBRFQRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Histone H2B (21-35) is a peptide fragment of histone H2B that corresponds to amino acid residues 22-36 of the human histone H2B sequence. Histone H2B (21-35) contains an aspartic acid at position 25 that spontaneously converts to isoaspartic acid at physiological pH in vitro and in vivo and induces production of autoantibodies against histone H2B in murine models of systemic lupus erythematosus (SLE).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Doyle, H.A., Aswad, D.W., and Mamula, M.J. Autoimmunity to isomerized histone H2B in systemic lupus erythematosus. Autoimmunity 46(1), 6-13 (2013).