A fungal metabolite
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Aranorosin

Item No. 27478

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E,4E,6R)-N-[(1α,2β,3α,4'S,5α,5'R,7α)-dihydro-5'-hydroxy-6-oxospiro[4,8-dioxatricyclo[5.1.0.03,5]octane-2,2'(3'H)-furan]-4'-yl]-4,6-dimethyl-2,4-dodecadienamide
CAS Number
117184-53-9
Molecular Formula
C23H33NO6
Formula Weight
419.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleEthanol: 1 mg/mlMethanol: Soluble
λmax
265 nm
SMILES
O=C1[C@H]2[C@H](O2)[C@]3(O[C@@H](O)[C@@H](NC(/C=C/C(C)=C/[C@H](C)CCCCCC)=O)C3)[C@H]4[C@@H]1O4
InChi Code
InChI=1S/C23H33NO6/c1-4-5-6-7-8-13(2)11-14(3)9-10-16(25)24-15-12-23(30-22(15)27)20-18(28-20)17(26)19-21(23)29-19/h9-11,13,15,18-22,27H,4-8,12H2,1-3H3,(H,24,25)/b10-9+,14-11+/t13-,15+,18-,19+,20-,21+,22-,23-/m1/s1
InChi Key
JHTWWPWUODMKEO-ZVNJHPNESA-N
Origin
Fungus/Gymnascella sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

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    Product Description

    Aranorosin is a fungal metabolite originally isolated from P. roseus.1 It has antimicrobial activity against B. subtilis, A. niger, and C. albicans when used at a concentration of 1 mg/ml. Aranorosin also reduces viability in apoptosis-resistant HeLa/Bcl-2 cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vijayakumar, E.K.S., Roy, K., Chatterjee, S., et al. Structure-activity relationships of new aranorosin analogs to antifungal activity. J. Antibiot. (Tokyo) 51(5), 522-524 (1998).

    2. Nakashima, T., Tanaka, R., Yamashita, Y., et al. Aranorosin and a novel derivative inhibit the anti-apoptotic functions regulated by Bcl-2. Biochem. Biophys. Res. Commun. 377(4), 1085-1090 (2008).