A peptide fragment of histone H3
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Histone H3K79Me3 (73-83) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

Item No. 27490

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-glutamyl-L-isoleucyl-L-alanyl-L-glutaminyl-L-α-aspartyl-L-phenylalanyl-6-(trimethylammonio)-L-norleucyl-L-threonyl-L-α-aspartyl-L-leucyl-L-arginine, trifluoroacetate salt
Synonyms
  • EIAQDF-K(Me3)-TDLR
  • H3K79me3, Histone H3 (73-83) (Lys79me3)
  • H-Glu-Ile-Ala-Gln-Asp-Phe-Lys(Me3)-Thr-Asp-Leu-Arg-OH
  • [Lys(Me3)79]-Histone H3 (73-83)
Molecular Formula
C61H101N16O20 • XCF3COO
Formula Weight
1378.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
O=C([O-])C(F)(F)F.C[N+](C)(C)CCCC[C@H](NC([C@H](CC1=CC=CC=C1)NC([C@H](CC(O)=O)NC([C@@H](NC([C@H](C)NC([C@@]([H])(NC([C@@H](N)CCC(O)=O)=O)[C@@H](C)CC)=O)=O)CCC(N)=O)=O)=O)=O)C(N[C@]([H])(C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CC(C)C)=O)=O)[C@H](O)C)=O
InChi Code
InChI=1S/C61H100N16O20.C2HF3O2/c1-10-32(4)48(75-51(87)36(62)21-24-45(80)81)58(94)67-33(5)50(86)68-38(22-23-44(63)79)52(88)73-42(29-46(82)83)56(92)72-41(28-35-17-12-11-13-18-35)55(91)69-37(19-14-15-26-77(7,8)9)53(89)76-49(34(6)78)59(95)74-43(30-47(84)85)57(93)71-40(27-31(2)3)54(90)70-39(60(96)97)20-16-25-66-61(64)65;3-2(4,5)1(6)7/h11-13,17-18,31-34,36-43,48-49,78H,10,14-16,19-30,62H2,1-9H3,(H19-,63,64,65,66,67,68,69,70,71,72,73,74,75,76,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97);(H,6,7)/t32-,33-,34+,36-,37-,38-,39-,40-,41-,42-,43-,48-,49-;/m0./s1
InChi Key
IJYRWOIKCWJYNU-ZCRTVYFESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $666

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    Product Description

    Histone H3K79Me3 (73-83) is a peptide fragment of histone H3 that corresponds to amino acid residues 74-84 of the human histone H3 sequence. Trimethylation of histone H3 at lysine 79 is found at promoter regions of both active and silenced genes in human CD4+ T cells and positively correlates with transcriptional repression.1 H3K79 trimethylation is also found at pericentromeric heterochromatin in mouse oocytes and somatic cells.2 Levels of H3K79Me3 are decreased in human tumor tissue compared to non-cancerous tissue.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Barski, A., Cuddapah, S., Cui, K., et al. High-resolution profiling of histone methylations in the human genome. Cell 129(4), 823-837 (2007).

    2. Ooga, M., Inoue, A., Kageyama, S., et al. Changes in H3K79 methylation during preimplantation development in mice. Biol. Reprod. 78(3), 413-424 (2008).

    3. Evanno, E., Godet, J., Piccirilli, N., et al. Tri-methylation of H3K79 is decreased in TGF-β1-induced epithelial-to-mesenchymal transition in lung cancer. Clin. Epigenetics 9, 80 (2017).