A peptide fragment of histone H3
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Histone H3K4Me1 (1-10) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

Item No. 27491

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2-L-alanyl-L-arginyl-L-threonyl-N6-methyl-L-lysyl-L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-L-lysyl-L-serine, trifluoroacetate salt
Synonyms
  • ART-K(Me1)-QTARKS
  • H-Ala-Arg-Thr-Lys(Me1)-Gln-Thr-Ala-Arg-Lys-Ser-OH
  • [Lys(Me1)4]-Histone H3 (1-10)
  • Histone H3 (1-10) (Lys4me1)
  • H3K4me1
Molecular Formula
C47H89N19O15 • XCF3COOH
Formula Weight
1160.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
CNCCCC[C@H](NC([C@@]([H])(NC([C@@H](NC([C@H](C)N)=O)CCCNC(N)=N)=O)[C@H](O)C)=O)C(N[C@H](C(N[C@]([H])(C(N[C@@H](C)C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CO)=O)CCCCN)=O)CCCNC(N)=N)=O)=O)[C@H](O)C)=O)CCC(N)=O)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C47H89N19O15/c1-23(49)36(71)59-30(15-11-21-57-47(53)54)41(76)66-35(26(4)69)44(79)63-28(13-7-9-19-55-5)38(73)62-31(16-17-33(50)70)42(77)65-34(25(3)68)43(78)58-24(2)37(72)60-29(14-10-20-56-46(51)52)39(74)61-27(12-6-8-18-48)40(75)64-32(22-67)45(80)81/h23-32,34-35,55,67-69H,6-22,48-49H2,1-5H3,(H2,50,70)(H,58,78)(H,59,71)(H,60,72)(H,61,74)(H,62,73)(H,63,79)(H,64,75)(H,65,77)(H,66,76)(H,80,81)(H4,51,52,56)(H4,53,54,57)/t23-,24-,25+,26+,27-,28-,29-,30-,31-,32-,34-,35-/m0/s1
InChi Key
OUKYPIQXABWWTF-NCKQPBNLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $334

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    Product Description

    Histone H3K4Me1 (1-10) is an N-terminal fragment of histone H3 that corresponds to amino acid residues 2-11 of the human histone H3 sequence. Monomethylation of histone H3 at lysine 4 is found at active and primed enhancer regions of gene promoters and H3K4Me1-containing nucleosomes are more efficiently remodeled by the chromatin-remodeling complex BAF than unmarked nucleosomes.1,2 It is also enriched at CpG sites associated with aging in stem and differentiated cells.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gupta, J., Kumar, S., Li, J., et al. Histone H3 lysine 4 monomethylation (H3K4me1) and H3 lysine 9 monomethylation (H3K9me1): Distribution and their association in regulating gene expression under hyperglycaemic/hyperinsulinemic conditions in 3T3 cells. Biochimie 94(12), 2656-2664 (2012).

    2. Local, A., Huang, H., Albuquerque, C.P., et al. Identification of H3K4me1-associated proteins at mammalian enhancers. Nat. Genet. 50(1), 73-82 (2018).

    3. Fernández, A.F., Bayón, G.F., Urdinguio, R.G., et al. H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells. Genome Res. 25(1), 27-40 (2015).