A peptide fragment of histone H3
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Histone H3K4Me2 (1-10) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

Item No. 27492

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-alanyl-L-arginyl-L-threonyl-6-(dimethylamino)-L-norleucyl-L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-L-lysyl-L-serine, trifluoroacetate salt
Synonyms
  • ART-K(Me2)-QTARKS
  • H-Ala-Arg-Thr-Lys(Me2)-Gln-Thr-Ala-Arg-Lys-Ser-OH
  • Histone H3 (1-10) (Lys4me2)
  • [Lys(Me2)4]-Histone H3 (1-10)
Molecular Formula
C48H91N19O15 • XCF3COOH
Formula Weight
1174.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
O=C(O)C(F)(F)F.CN(C)CCCC[C@H](NC([C@@]([H])(NC([C@@H](NC([C@H](C)N[H])=O)CCCNC(N)=N)=O)[C@H](O)C)=O)C(N[C@H](C(N[C@]([H])(C(N[C@@H](C)C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CO)=O)CCCCN)=O)CCCNC(N)=N)=O)=O)[C@H](O)C)=O)CCC(N)=O)=O
InChi Code
InChI=1S/C48H91N19O15.C2HF3O2/c1-24(50)37(72)59-31(16-12-21-57-48(54)55)42(77)66-36(27(4)70)45(80)63-29(14-8-10-22-67(5)6)39(74)62-32(17-18-34(51)71)43(78)65-35(26(3)69)44(79)58-25(2)38(73)60-30(15-11-20-56-47(52)53)40(75)61-28(13-7-9-19-49)41(76)64-33(23-68)46(81)82;3-2(4,5)1(6)7/h24-33,35-36,68-70H,7-23,49-50H2,1-6H3,(H2,51,71)(H,58,79)(H,59,72)(H,60,73)(H,61,75)(H,62,74)(H,63,80)(H,64,76)(H,65,78)(H,66,77)(H,81,82)(H4,52,53,56)(H4,54,55,57);(H,6,7)/t24-,25-,26+,27+,28-,29-,30-,31-,32-,33-,35-,36-;/m0./s1
InChi Key
QDHBAEGTUPGHIU-QXSBRIHGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $224

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    Product Description

    Histone H3K4Me2 (1-10) is an N-terminal peptide fragment of histone H3 that corresponds to amino acid residues 2-11 of the human histone H3 sequence. Dimethylation of histone H3 at lysine 4 is found at active and primed, but inactive, loci.1,2 It is enriched in gene promoter regions and overlaps with transcription factor binding sites. Low tumor levels of H3K4Me2 positively correlate with decreased overall and disease-free survival in pancreatic cancer patients.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sims, R.J., III, and Reinberg, D. Histone H3 Lys 4 methylation: Caught in a bind? Genes Dev. 20(20), 2779-2786 (2006).

    2. Wang, Y., Li, X., and Hu, H. H3K4me2 reliably defines transcription factor binding regions in different cells. Genomics 103(2-3), 222-228 (2014).

    3. Watanabe, T., Morinaga, S., Akaike, M., et al. The cellular level of histone H3 lysine 4 dimethylation correlates with response to adjuvant gemcitabine in Japanese pancreatic cancer patients treated with surgery. Eur. J. Surg. Oncol. 38(11), 1051-1057 (2012).