A peptide fragment of histone H3
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Histone H3 (1-15) (Phospho-Ser10) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

Item No. 27494

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-L-alanyl-L-arginyl-L-threonyl-L-lysyl-L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-L-lysyl-O-phosphono-L-seryl-L-threonylglycylglycyl-L-lysyl-L-alanine, trifluoroacetate salt
Synonyms
  • ARTKQTARK-pS-TGGKA
  • [pSer10]-Histone H3 (1-15)
  • 1-15 H3pS10
  • H3S10ph (1-15)
  • H31-15S10ph
Molecular Formula
C63H118N25O24P • XCF3COOH
Formula Weight
1640.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
O=C(O)C(F)(F)F.C[C@@H](O)[C@@]([H])(C(NCC(NCC(N[C@H](C(N[C@@H](C)C(O)=O)=O)CCCCN)=O)=O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C)NC([C@@]([H])(NC([C@@H](NC([C@@H](NC([C@@]([H])(NC([C@@H](NC([C@H](C)N)=O)CCCNC(N)=N)=O)[C@H](O)C)=O)CCCCN)=O)CCC(N)=O)=O)[C@H](O)C)=O)=O)CCCNC(N)=N)=O)CCCCN)=O)COP(O)(O)=O)=O
InChi Code
InChI=1S/C63H118N25O24P.C2HF3O2/c1-30(67)49(95)80-40(19-14-26-74-63(71)72)55(101)88-48(35(6)91)60(106)84-38(17-9-12-24-66)52(98)83-41(20-21-43(68)92)56(102)87-47(34(5)90)59(105)77-31(2)50(96)81-39(18-13-25-73-62(69)70)53(99)82-37(16-8-11-23-65)54(100)85-42(29-112-113(109,110)111)57(103)86-46(33(4)89)58(104)76-27-44(93)75-28-45(94)79-36(15-7-10-22-64)51(97)78-32(3)61(107)108;3-2(4,5)1(6)7/h30-42,46-48,89-91H,7-29,64-67H2,1-6H3,(H2,68,92)(H,75,93)(H,76,104)(H,77,105)(H,78,97)(H,79,94)(H,80,95)(H,81,96)(H,82,99)(H,83,98)(H,84,106)(H,85,100)(H,86,103)(H,87,102)(H,88,101)(H,107,108)(H4,69,70,73)(H4,71,72,74)(H2,109,110,111);(H,6,7)/t30-,31-,32-,33+,34+,35+,36-,37-,38-,39-,40-,41-,42-,46-,47-,48-;/m0./s1
InChi Key
BGYUIWIBNPSWOU-GJIGDEGVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Histone H3 (1-15) (phospho-Ser10) is a peptide fragment that corresponds to amino acid residues 2-16 of the human histone H3 sequence. Phosphorylation of histone H3 at serine 10 is correlated with chromatin condensation during mitosis and with transcriptional activation of genes during interphase.1,2 Histone H3 (1-15) (phospho-Ser10) does not inhibit binding of the ADD domain of the chromatin-remodeling protein ATRX to histone H3 due to its positioning away from the core peptide binding sequence but does decrease binding of the HP1α chromodomain (CD) when histone H3 is also methylated at lysine 9.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sawicka, A., and Seiser, C. Histone H3 phosphorylation - A versatile chromatin modification for different occasions. Biochimie 94(11), 2193-2201 (2012).

    2. Prigent, C., and Dimitrov, S. Phosphorylation of serine 10 in histone H3, what for? J. Cell. Sci. 116(Pt. 18), 3677-3685 (2003).

    3. Noh, K.M., Maze, I., Zhao, D., et al. ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons. Proc. Natl. Acad. Sci. USA 112(22), 6820-6827 (2015).