A peptide fragment of histone H3
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Histone H3K9Ac (1-20) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

Item No. 27498

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-alanyl-L-arginyl-L-threonyl-L-lysyl-L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-N6-acetyl-L-lysyl-L-seryl-L-threonylglycylglycyl-L-lysyl-L-alanyl-L-prolyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucine, trifluoroacetate salt
Synonyms
  • ARTKQTAR-K(Ac)-STGGKAPRKQL
  • Histone H3 (1-20) (Lys9ac)
  • [Lys(Ac)9]-Histone H3 (1-20)
Molecular Formula
C93H169N35O28 • XCF3COOH
Formula Weight
2225.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
O=C(O)C(F)(F)F.CC(NCCCC[C@@H](C(N[C@@H](CO)C(N[C@]([C@@H](C)O)([H])C(NCC(NCC(N[C@@H](CCCCN)C(N[C@H](C(N1CCC[C@H]1C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](CCC(N)=O)NC([C@H](CCCCN)NC([C@@]([C@@H](C)O)([H])NC([C@H](CCCNC(N)=N)NC([C@@H](N[H])C)=O)=O)=O)=O)=O)=O)C)=O)=O)=O
InChi Code
InChI=1S/C93H169N35O28.C2HF3O2/c1-46(2)42-63(90(155)156)123-81(146)61(30-32-66(98)134)119-76(141)55(23-11-15-35-95)117-79(144)59(27-19-39-108-92(102)103)121-85(150)65-29-21-41-128(65)89(154)49(5)113-75(140)54(22-10-14-34-94)114-69(137)44-110-68(136)43-111-86(151)70(50(6)130)125-84(149)64(45-129)124-80(145)56(25-13-17-37-106-53(9)133)118-78(143)58(26-18-38-107-91(100)101)116-74(139)48(4)112-87(152)71(51(7)131)126-83(148)62(31-33-67(99)135)120-77(142)57(24-12-16-36-96)122-88(153)72(52(8)132)127-82(147)60(115-73(138)47(3)97)28-20-40-109-93(104)105;3-2(4,5)1(6)7/h46-52,54-65,70-72,129-132H,10-45,94-97H2,1-9H3,(H2,98,134)(H2,99,135)(H,106,133)(H,110,136)(H,111,151)(H,112,152)(H,113,140)(H,114,137)(H,115,138)(H,116,139)(H,117,144)(H,118,143)(H,119,141)(H,120,142)(H,121,150)(H,122,153)(H,123,146)(H,124,145)(H,125,149)(H,126,148)(H,127,147)(H,155,156)(H4,100,101,107)(H4,102,103,108)(H4,104,105,109);(H,6,7)/t47-,48-,49-,50+,51+,52+,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,70-,71-,72-;/m0./s1
InChi Key
METFZEIWTCYTQS-IYCRWTGISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $356

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    Product Description

    Histone H3K9Ac (1-20) is an N-terminal peptide fragment that corresponds to amino acid residues 2-21 of the human histone H3 sequence. Acetylation of histone H3 at lysine 9 is associated with active gene transcription and can recruit the super elongation complex to chromatin through direct binding with the AF9 and ENL subunits.1,2 It increases at the IFN-β promoter in HeLa cells upon infection with Sendai virus.3 Acetylation of histone H3 at lysine 9 decreases following induction of DNA damage in HeLa and U2OS cells.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jenuwein, T., and Allis, C.D. Translating the histone code. Science 293(5532), 1074-1080 (2001).

    2. Agalioti, T., Chen, G., and Thanos, D. Deciphering the transcriptional histone acetylation code for a human gene. Cell 111(3), 381-392 (2002).

    3. Tjeertes, J.V., Miller, K.M., and Jackson, S.P. Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells. EMBO J. 28(13), 1878-1889 (2009).