A ROS-generating probe
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

MGR1

Item No. 27499

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2-dimethyl-propanoic acid, [(1,4,4a,9,9a,10-hexahydro-9,10-dioxo-1,4-ethanoanthracen-5-yl)oxy]methyl ester
CAS Number
2361529-46-4
Molecular Formula
C22H24O5
Formula Weight
368.4
Purity
≥98%
Formulation (Request formulation change)
A 1 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mLDMSO: 30 mg/mLEthanol: 30 mg/mL
λmax
227, 316 nm
SMILES
O=C1C2C(C3C=CC2CC3)C(C4=C(OCOC(C(C)(C)C)=O)C=CC=C41)=O
InChi Code
InChI=1S/C22H24O5/c1-22(2,3)21(25)27-11-26-15-6-4-5-14-18(15)20(24)17-13-9-7-12(8-10-13)16(17)19(14)23/h4-7,9,12-13,16-17H,8,10-11H2,1-3H3
InChi Key
XOQBQESWHYEJGY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $168

    Add

    1 mg

    $317

    Add
    Product Description

    MGR1 is a probe that generates reactive oxygen species (ROS).1 Upon activation by esterases, MGR1 produces superoxide in vitro, an effect that is reversed by superoxide dismutase (SOD). MGR1 produces ROS and increases production of oxidized phosphatidylserine species in HEK293T cells. It reduces viability of HEK293T cells (IC50s = 5.1-6.3 μM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kelkar, D., Ravikumar, G., Mehendale, N., et al. A chemical-genetic screen identifies ABHD12 as an oxidized-phosphatidylserine lipase. Nat. Chem. Biol. 15(2), 169-178 (2019).