A triterpenoid saponin with diverse biological activities
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Isomer(s)
37320Ziyuglycoside I
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Hederoside D2

Item No. 27507

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,4α)-3-[(2-O-β-D-glucopyranosyl-α-L-arabinopyranosyl)oxy]-23-hydroxy-olean-12-en-28-oic acid
CAS Number
20853-58-1
Molecular Formula
C41H66O13
Formula Weight
767.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 15 mg/mlEthanol: 5 mg/ml
SMILES
CC1(C)CC[C@@](CC[C@]2(C)C3=CC[C@@]4([H])[C@@]2(C)CC[C@]5([H])[C@]4(C)CC[C@H](O[C@]6([H])OC[C@H](O)[C@H](O)[C@H]6O[C@@]7([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)[C@@]5(C)CO)(C(O)=O)[C@@]3([H])C1
InChi Code
InChI=1S/C41H66O13/c1-36(2)13-15-41(35(49)50)16-14-39(5)21(22(41)17-36)7-8-26-37(3)11-10-27(38(4,20-43)25(37)9-12-40(26,39)6)53-34-32(28(45)23(44)19-51-34)54-33-31(48)30(47)29(46)24(18-42)52-33/h7,22-34,42-48H,8-20H2,1-6H3,(H,49,50)/t22-,23-,24+,25+,26+,27-,28-,29+,30-,31+,32+,33-,34-,37-,38-,39+,40+,41-/m0/s1
InChi Key
RROGHRHLBLVQSG-UUWFFIQNSA-N
Origin
Plant/Hedera helix
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Hederoside D2 is a triterpenoid saponin originally isolated from C. robustum rhizome and roots and has diverse biological activities.1,2 It induces potassium release and hemolysis in mouse erythrocytes in a pH-dependent manner when used at a concentration of 10 μg/ml.2 Hederoside D2 is cytotoxic to N1E-115 neuroblastoma cells at low pH. It induces proliferation of human embryonic fibroblasts in acidic medium, an effect that can be blocked by the calcium channel blockers verapamil (Item No. 14288), diltiazem, and nitrendipine (Item No. 17549).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Murakami, T., Nagasawa, M., Urayama, S., et al. New triterpenoid saponins in the rhizome and roots of Caulophyllum robustum. Yakugaku Zasshi 88(3), 321-324 (1968).

    2. Likhatskaya, G.N., Aminin, D.L., Agafonova, I.G., et al. The pH-dependent channels formed by cauloside C. Advances in Experimental Medicine and Biology 404, 239-249 (1996).