A biotinylated peptide fragment of histone H3
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Histone H3K14Ac/H3K23Ac (1-24)-GGK-biotin (trifluoroacetate salt)

Item No. 27520

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • ARTKQTARKSTGG-K(Ac)-APRKQLAT-K(Ac)-AGG-K(Biotin)
  • Histone H3 (1-24) (Lys14ac/Lys23ac)
  • [Lys(Ac)14/23]-Histone H3 (1-24)-GGK(Biotin)
Molecular Formula
C131H232N46O39S • XCF3COOH
Formula Weight
3107.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
O=C(NCCCC[C@@H](C(O)=O)NC(CNC(CNC([C@@H](NC([C@H](CCCCNC(C)=O)NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CCC(N)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@@H]1CCCN1C([C@@H](NC([C@H](CCCCNC(C)=O)NC(CNC(CNC([C@@]([C@@H](C)O)([H])NC([C@H](CO)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](CCC(N)=O)NC([C@H](CCCCN)NC([C@@]([C@@H](C)O)([H])NC([C@H](CCCNC(N)=N)NC([C@@H](N[H])C)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)C)=O)=O)=O)CCCC[C@@H]2SC[C@@](N3)([H])[C@]2([H])NC3=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C131H232N46O39S.C2HF3O2/c1-65(2)58-88(119(206)155-69(6)108(195)172-102(73(10)181)124(211)167-78(36-20-26-52-145-76(13)184)110(197)154-67(4)106(193)152-59-96(188)151-62-99(191)159-87(127(214)215)37-21-27-53-146-95(187)43-15-14-42-92-104-90(64-217-92)171-131(216)176-104)169-116(203)85(44-46-93(136)185)164-111(198)79(32-16-22-48-132)162-114(201)83(39-29-55-148-129(140)141)166-121(208)91-41-31-57-177(91)126(213)70(7)157-109(196)77(35-19-25-51-144-75(12)183)158-98(190)61-150-97(189)60-153-122(209)100(71(8)179)173-120(207)89(63-178)170-115(202)80(33-17-23-49-133)163-113(200)82(38-28-54-147-128(138)139)161-107(194)68(5)156-123(210)101(72(9)180)174-118(205)86(45-47-94(137)186)165-112(199)81(34-18-24-50-134)168-125(212)103(74(11)182)175-117(204)84(160-105(192)66(3)135)40-30-56-149-130(142)143;3-2(4,5)1(6)7/h65-74,77-92,100-104,178-182H,14-64,132-135H2,1-13H3,(H2,136,185)(H2,137,186)(H,144,183)(H,145,184)(H,146,187)(H,150,189)(H,151,188)(H,152,193)(H,153,209)(H,154,197)(H,155,206)(H,156,210)(H,157,196)(H,158,190)(H,159,191)(H,160,192)(H,161,194)(H,162,201)(H,163,200)(H,164,198)(H,165,199)(H,166,208)(H,167,211)(H,168,212)(H,169,203)(H,170,202)(H,172,195)(H,173,207)(H,174,205)(H,175,204)(H,214,215)(H4,138,139,147)(H4,140,141,148)(H4,142,143,149)(H2,171,176,216);(H,6,7)/t66-,67-,68-,69-,70-,71+,72+,73+,74+,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,100-,101-,102-,103-,104-;/m0./s1
InChi Key
JLPIJLHTTQTHGM-QWVPJBCYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 µg

    $224

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    Product Description

    Histone H3K14Ac/H3K23Ac (1-24)-GGK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 2-25 of the human histone H3 sequence. It is acetylated at lysine 14 and lysine 23 and biotinylated via a C-terminal GGK linker. Acetylation of H3K14 or H3K23 is associated with transcriptional activation and H3K14 acetylation is required for trimethylation of H3K4.1,2 H3K23 acetylation is decreased in wild-type but increased in uninephrectomized db/db mouse kidney.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Keating, S.T., van Diepen, J.A., Risken, N.P., et al. Epigenetics in diabetic nephropathy, immunity and metabolism. Diabetologia 61(1), 6-20 (2018).

    2. Nakanishi, S., Sanderson, B.W., Delventhal, K.M., et al. A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation. Nat. Struct. Mol. Biol. 15(8), 881-888 (2008).

    3. Sayyed, S.G., Gaikwad, A.B., Lichtnekert, J., et al. Progressive glomerulosclerosis in type 2 diabetes is associated with renal histone H3K9 and H3K23 acetylation, H3K4 dimethylation and phosphorylation at serine 10. Nephrol. Dial. Transplant. 25(6), 1811-1817 (2010).