A peptide fragment of histone H3
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Histone H3K4Me3 (1-25) amide (human mouse, rat, porcine, bovine) (trifluoroacetate salt)

Item No. 27522

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-alanyl-L-arginyl-L-threonyl-6-(trimethylammonio)-L-norleucyl-L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-threonylglycylglycyl-L-lysyl-L-alanyl-L-prolyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucyl-L-alanyl-L-threonyl-L-lysyl-L-alanyl-L-alaninamide, trifluoroacetate salt
Synonyms
  • ART-K(Me3)-QTARKSTGGKAPRKQLATKAA-NH2
  • Histone H3 (1-25) (Lys4me3)
  • H3K4me3
  • [Lys(Me3)4]-Histone H3 (1-25) amide
Molecular Formula
C113H209N42O32 • XCF3COO
Formula Weight
2668.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
O=C([O-])C(F)(F)F.NC([C@H](C)NC([C@H](C)NC([C@@H](NC([C@@]([H])(NC([C@H](C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]1CCCN1C([C@H](C)NC([C@@H](NC(CNC(CNC([C@@]([H])(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C)NC([C@@]([H])(NC([C@@H](NC([C@@H](NC([C@@]([H])(NC([C@@H](NC([C@H](C)N)=O)CCCNC(N)=N)=O)[C@H](O)C)=O)CCCC[N+](C)(C)C)=O)CCC(N)=O)=O)[C@H](O)C)=O)=O)CCCNC(N)=N)=O)CCCCN)=O)CO)=O)[C@H](O)C)=O)=O)=O)CCCCN)=O)=O)=O)CCCNC(N)=N)=O)CCCCN)=O)CCC(N)=O)=O)CC(C)C)=O)=O)[C@H](O)C)=O)CCCCN)=O)=O)=O
InChi Code
InChI=1S/C113H208N42O32.C2HF3O2/c1-56(2)52-77(103(180)135-61(7)92(169)150-86(65(11)159)108(185)146-68(31-17-22-44-115)94(171)134-59(5)90(167)133-58(4)88(121)165)148-100(177)75(39-41-80(119)161)143-95(172)69(32-18-23-45-116)141-98(175)73(36-27-48-129-112(124)125)145-105(182)79-38-29-50-154(79)110(187)62(8)137-93(170)67(30-16-21-43-114)138-83(164)54-131-82(163)53-132-106(183)84(63(9)157)151-104(181)78(55-156)149-99(176)70(33-19-24-46-117)142-97(174)72(35-26-47-128-111(122)123)140-91(168)60(6)136-107(184)85(64(10)158)152-102(179)76(40-42-81(120)162)144-96(173)71(34-20-25-51-155(13,14)15)147-109(186)87(66(12)160)153-101(178)74(139-89(166)57(3)118)37-28-49-130-113(126)127;3-2(4,5)1(6)7/h56-79,84-87,156-160H,16-55,114-118H2,1-15H3,(H40-,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150,151,152,153,161,162,163,164,165,166,167,168,169,170,171,172,173,174,175,176,177,178,179,180,181,182,183,184,185,186);(H,6,7)/t57-,58-,59-,60-,61-,62-,63+,64+,65+,66+,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,84-,85-,86-,87-;/m0./s1
InChi Key
SXLNNWJFGBGNNJ-KYAVQZSNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 µg

    $224

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    Product Description

    Histone H3K4Me3 (1-25) amide is an N-terminal peptide fragment of histone H3 that corresponds to amino acid residues 2-26 of the human histone H3 sequence. Trimethylation of histone H3 at lysine 4 is found in euchromatic promoter regions and is associated with active transcription.1 It inhibits several H3K9 methyltransferases and has differential effects on the activities of the KDM7 demethylases PHF8 and KDM7A, activating and inhibiting H3K9Me3 demethylation, respectively. Mislocalization of H3K4Me3 is associated with disease progression and memory deficits in patients with Alzheimer's disease.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pack, L.R., Yamamoto, K.R., and Fujimori, D.G. Opposing chromatin signals direct and regulate the activity of lysine demethylase 4C (KDM4C). The Journal of Biological Chemisty 291(12), 6060-6070 (2016).

    2. Mastroeni, D., Delvaux, E., Nolz, J., et al. Aberrant intracellular localization of H3k4me3 demonstrates an early epigenetic phenomenon in Alzheimer’s disease. Neurobiol. Aging 36(12), 3121-3129 (2015).