A biotinylated fragment of histone H3
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Histone H3K14Ac/K18Ac/K23Ac/K27Ac (1-30)-GGK-biotin (trifluoroacetate salt)

Item No. 27523

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • ARTKQTARKSTGG-K(Ac)-APR-K(Ac)-QLAT-K(Ac)-AAR-K(Ac)-SAPGG-K(biotin)
  • Histone H3 (1-30) (Lys14ac/Lys18ac/Lys23ac/Lys27ac)
  • [Lys(Ac)14/18/23/27]-Histone H3 (1-30)-GGK(biotin)
Molecular Formula
C161H282N56O48S • XCF3COOH
Formula Weight
3802.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
CC(NCCCC[C@@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCNC(C)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCCCNC(C)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCNC(C)=O)C(N[C@@H](CO)C(N[C@H](C(N2CCC[C@H]2C(NCC(NCC(N[C@@H](CCCCNC(CCCC[C@@H]3SC[C@@](N4)([H])[C@]3([H])NC4=O)=O)C(O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)C)=O)C)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)C)=O)NC(CNC(CNC([C@@]([C@@H](C)O)([H])NC([C@H](CO)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](CCC(N)=O)NC([C@H](CCCCN)NC([C@@]([C@@H](C)O)([H])NC([C@H](CCCNC(N)=N)NC([C@@H](N[H])C)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C161H282N56O48S.C2HF3O2/c1-80(2)72-109(145(252)190-85(7)132(239)211-125(90(12)222)152(259)205-97(43-23-30-62-176-93(15)225)134(241)189-82(4)129(236)188-83(5)130(237)197-102(47-34-66-180-157(167)168)138(245)201-100(45-25-32-64-178-95(17)227)141(248)208-110(77-218)146(253)193-87(9)154(261)216-70-38-51-113(216)148(255)186-73-119(231)185-76-122(234)195-108(156(263)264)46-26-33-65-179-118(230)54-19-18-53-115-127-112(79-266-115)210-161(265)215-127)207-142(249)106(55-57-116(165)228)202-135(242)99(44-24-31-63-177-94(16)226)200-139(246)104(49-36-68-182-159(171)172)204-149(256)114-52-39-71-217(114)155(262)86(8)192-133(240)96(42-22-29-61-175-92(14)224)194-121(233)75-184-120(232)74-187-150(257)123(88(10)220)212-147(254)111(78-219)209-140(247)98(40-20-27-59-162)199-137(244)103(48-35-67-181-158(169)170)198-131(238)84(6)191-151(258)124(89(11)221)213-144(251)107(56-58-117(166)229)203-136(243)101(41-21-28-60-163)206-153(260)126(91(13)223)214-143(250)105(196-128(235)81(3)164)50-37-69-183-160(173)174;3-2(4,5)1(6)7/h80-91,96-115,123-127,218-223H,18-79,162-164H2,1-17H3,(H2,165,228)(H2,166,229)(H,175,224)(H,176,225)(H,177,226)(H,178,227)(H,179,230)(H,184,232)(H,185,231)(H,186,255)(H,187,257)(H,188,236)(H,189,241)(H,190,252)(H,191,258)(H,192,240)(H,193,253)(H,194,233)(H,195,234)(H,196,235)(H,197,237)(H,198,238)(H,199,244)(H,200,246)(H,201,245)(H,202,242)(H,203,243)(H,204,256)(H,205,259)(H,206,260)(H,207,249)(H,208,248)(H,209,247)(H,211,239)(H,212,254)(H,213,251)(H,214,250)(H,263,264)(H4,167,168,180)(H4,169,170,181)(H4,171,172,182)(H4,173,174,183)(H2,210,215,265);(H,6,7)/t81-,82-,83-,84-,85-,86-,87-,88+,89+,90+,91+,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,123-,124-,125-,126-,127-;/m0./s1
InChi Key
NSLUQXYZNSRELK-RFNOJIOGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 µg

    $262

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    Product Description

    Histone H3K14Ac/K18Ac/K23Ac/K27Ac (1-30)-GGK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 2-31 of the human histone H3 sequence. It is acetylated at lysine 14, lysine 18, lysine 23, and lysine 27 and biotinylated via a C-terminal GGK linker. Acetylation of H3K14, H3K18, H3K23, or H3K27 is associated with transcriptional activation, and H3K14 acetylation is required for trimethylation of H3K4.1,2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kimura, H. Histone modifications for human epigenome analysis. J. Hum. Genet. 58(7), 439-445 (2013).

    2. Keating, S.T., van Diepen, J.A., Risken, N.P., et al. Epigenetics in diabetic nephropathy, immunity and metabolism. Diabetologia 61(1), 6-20 (2018).

    3. Nakanishi, S., Sanderson, B.W., Delventhal, K.M., et al. A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation. Nat. Struct. Mol. Biol. 15(8), 881-888 (2008).

    4. Barber, M.F., Michishita-Kioi, E., Xi, Y., et al. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature 487(7405), 114-118 (2012).